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EC number: 221-259-8 | CAS number: 3048-64-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Vinyl norbornene is expected to have a relatively low degree of acute toxicity. Results for VNB are available for all routes of exposure:
Oral LD50: All rat. male: 5239mg/kg, female: 10567mg/kg
Inhalation LC50: Rat male: 11.2mg/l, female: 12.6mg/l.
Dermal, rabbit LD50: >8ml/kg
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Comparable to guideline study. Well documented study which meets basic scientific principles.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: between 200-300 grams - Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- Animals were dosed orally by gavage (liquid).
- Doses:
- 1.25, 2.5, 5, 7.1, 10, 19.9 ml/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: daily. Weighed 7 and 14 days after dosing.
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 5 239 mg/kg bw
- 95% CL:
- 4 539 - 6 127
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 10 567 mg/kg bw
- 95% CL:
- 5 950 - 187 368
- Clinical signs:
- other: Clinical signs of toxicity were observed in dose groups. At the lowest dose, these were limited to sluggishness and unkemp appearance. At higher doses, also seen were lacrimation, kyphosis, unsteady gait and diarrhea, which appeared within 30-45 min pos
- Gross pathology:
- The only consistent finding at necropsy of rats that died was mottled dark pink or red lungs. No gross pathology was seen in survivors at necropsy.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 values indicate a low degree of toxicity. Females had a LD50 value numerically about twice that for males. The marginally significant difference in LD50 values between males and females were due mainly to the greater variability of females to the peroral toxicity of ENB.
- Executive summary:
Ballantyne et al (1997) published acute oral LD50 values of ~5200 mg/kg (males) and 10500 mg/kg (females) for vinyl norbornene in rats.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 200 mg/kg bw
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Comparable to guideline study. Well documented study which meets basic scientific principles.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Principles of method if other than guideline:
- Method not specified
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Vapour produced by metered piston pump delivering liquid into a heated evaporator at 40-50C
- Exposure chamber volume: 1300litre
- Method of holding animals in test chamber:
- Source and rate of air: 250litre/min
TEST ATMOSPHERE
- Brief description of analytical method used: gas sampler and GC/FID every 5 minutes. Nominal concentrations based on mass volume consumed.
- Samples taken from breathing zone: no - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 1551, 2084, 2365, 2682, 3259 ppm.
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days (or other?)
- Frequency of observations and weighing: daily. Weighted at 7 and 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology. - Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 2 231 ppm
- 95% CL:
- 1 938 - 2 568
- Exp. duration:
- 4 h
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- 2 518 ppm
- 95% CL:
- 2 268 - 2 796
- Exp. duration:
- 4 h
- Mortality:
- Males: 0/5, 1/5, 3/5, 5/5, 4/5 at each dose. For females, none died up to 2365ppm, all died at 2682ppm and above.
- Clinical signs:
- other: At approximately the LC50 concentration, animals exhibited hind leg paralysis in 7/20 animals post exposure. Hypereactivity, tremors, and convulsions also reported.
- Body weight:
- Decreased body weight was seen at 2084ppm but not at 1581ppm.
- Gross pathology:
- No gross pathology was reported..
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The 4-hr LC50 value indicates a moderate degree of vapor toxicity. At these high vapor concentration, signs are predominantly those of a central excitatory nature, particularly hypereactivity, tremors, and convulsions.
- Executive summary:
In a reliable study, Ballantyne et al (1997) published acute 4 -hr LC50 values of 2231 ppm (11.2 mg/l) (males) and 2518 ppm (12.6 mg/l) (females) for vinyl norbornene vapor in rats.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 11.2 mg/m³ air
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Comparable to guideline study. Well documented study which meets basic scientific principles.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- . Only two doses given.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hazelton Research Products Inc, Denver, PA
- Weight at study initiation: between 2-3 kg
- Housing: singly in wire mesh cages.
- Acclimation period: 2 weeks
ENVIRONMENTAL CONDITIONS
- Photoperiod (hrs dark / hrs light): 12/12 - Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: clipped dorsal trunk
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no. Excess wiped away after occlusive dressings removed. - Duration of exposure:
- 24 hr
- Doses:
- 8.0, 16 mL/kg
- No. of animals per sex per dose:
- High dose group 4, low dose group 5.
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily observations. Weighing at 7 and 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, gross pathology. - Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 16 mL/kg bw
- Mortality:
- One male died in the high dose group on day 4.
- Clinical signs:
- other: Signs of possible systemic effects were few and included almost immediate vocalization on applying the dose, persisting for about 5-15 min. Sluggishness and laboured breathing were seen with a few males. On removal of the occlusive dressing there was som
- Gross pathology:
- No gross pathology was observed at necropsy in most survivors, although a few had dark or bright red lungs. The one deceased animal showed mottled liver and multiple black foci in the stomach wall.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Undiluted VNB produced slight acute percutaneous systemic toxicity and severe irritancy by single 24-hr contact with skin.
- Executive summary:
Ballantyne et al (1997) published an acute (24 -hr occlusive exposure) dermal LD50 value of >16ml/kg (13.8g/kg) for vinyl norbornene in rabbits.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 13 800 mg/kg bw
Additional information
There are reliable acute toxicity studies on the substance vinyl norbornene (VNB) by the inhalation route, the oral route and the dermal route. The acute oral LD50value was 5239 mg/kg for male rats and 10567 mg/kg for female rats. The acute inhalation LC50values were 11.2 mg/L for male rats and 12.6 mg/L for female rats. The dermal LD50value was greater than 16ml/kg (13800 mg/kg) for male and female rabbits.
Justification for selection of acute toxicity – oral endpoint
Only available study in dossier
Justification for selection of acute toxicity – inhalation endpoint
Only available study in dossier
Justification for selection of acute toxicity – dermal endpoint
Only available study in dossier
Justification for classification or non-classification
Based on the available animal data, there is sufficient information available to determine that no classification is required for the oral, and dermal routes of acute exposure. Classification as acute toxicity category 4 under the CLP regulation and Xn under directive 67/548 is required for the inhalation route.
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