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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 202-179-2 | CAS number: 92-69-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP study, pre-dates OECD guidelines, limitations in reporting but acceptable design.
- Justification for data waiving:
- other:
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
- Principles of method if other than guideline:
- Rabbit patch test
Based on: Code of Federal Regulations, Title 16, Section 1500.41 - GLP compliance:
- no
Test material
- Reference substance name:
- p-Phenylphenol
- IUPAC Name:
- p-Phenylphenol
- Test material form:
- not specified
- Details on test material:
- Substance: p-Phenylphenol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: laboratory animal breeder W. Ostrop / Meerbusch
- Housing: The animals were housed individually in cages
- Weight: average weight of 2.8 kg
- Diet (e.g. ad libitum): provided with “Mümmel Z” feed (ssniff / Soest) ad libitum
- Water (e.g. ad libitum): water ad libitum
ENVIRONMENTAL CONDITIONS (Rearing conditions)
- Temperature (°C): 16 -18
- Humidity (%): 40 (relative humidity)
- Photoperiod (hrs dark / hrs light): 12 - hour light/dark cycle
- Other:
- Male rabbits.
- Habituation period 7 - 14 d.
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: left and right rump clipped and right side abraded
- Vehicle:
- other: oil used to form a paste
- Controls:
- not required
- Amount / concentration applied:
- 500 mg of the substance mixed with oil to form a paste
- Duration of treatment / exposure:
- 24 hour
- Observation period:
- Findings were recorded immediately (approx. 30 min) after removal of the patches (24-hour reading), and then 48h and 72h after the start of the test (48h after the first reading). The 48h reading does not appear in the report sheet. The control findings after 8d are not taken into account in calculating the irritation index.
- Number of animals:
- 6
- Details on study design:
- Test execution: 24 hours before the start of the test, an area of flank skin measuring approx. 8 x 8 cm on either side of the rump of 6 rabbits with an average weight of 2.8 kg was shaved using electric hair clippers. The skin on the right flank was additionally scratched with the aid of a scarificator in the area where the test patches were to be applied. 2.5 x 2.5 cm patches of double - layered surgical gauze were coated with/soaked in 500 mg of the substance mixed with oil to form a paste and covered with inert, impermeable PVC film (5 x 5 cm).
The film with the patches underneath it was attached to the two test areas with the aid of skin - friendly adhesives strips (Leukoflex). Then the animal’s entire rump was wrapped in elastic bandage (EloflexR) for the duration of the 24 - hour exposure time. The animals were immobilised.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24, 72 hours
- Score:
- 1.1
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24, 72 hours
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
Any other information on results incl. tables
- See attached report for Results - individual scores - total score - PRIMARY SKIN IRRITATION in rabbits
- Primary irritation index: 13.0 / 4 = 3.3
- Classification: moderate irritant
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- The product is thus classified as a moderate irritant to the skin.
- Executive summary:
- The aforementioned product yielded a primary irritation index of 3.3 in the primary skin irritation study conducted in accordance with Code of Federal Regulations, Title 16, Section 1500.41.
- The product is thus classified as a moderate irritant to the skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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