Registration Dossier
Registration Dossier
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EC number: 258-083-6 | CAS number: 52664-35-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Tris(4-aminophenyl) thiophosphate
- EC Number:
- 258-083-6
- EC Name:
- Tris(4-aminophenyl) thiophosphate
- Cas Number:
- 52664-35-4
- Molecular formula:
- C18H18N3O3PS
- IUPAC Name:
- O,O,S-tris(4-aminophenyl) thiophosphate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- other: Contralateral skin area not treated with the test substance served as control.
- Duration of treatment / exposure:
- 4 h
- Observation period:
- 24 h, 48 h, 72 h, 7 d
- Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Remarks:
- erythema and eschar formation
- Basis:
- mean
- Time point:
- other: 1h, 24h, 48h, 72h, 7d
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- overall irritation score
- Remarks:
- oedema formation
- Basis:
- mean
- Time point:
- other: 1h, 24h, 48h, 72h, 7d
- Score:
- 0
- Max. score:
- 0
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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