Registration Dossier
Registration Dossier
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EC number: 232-136-3 | CAS number: 7787-93-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study in compliance with GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 007787-93-1
- Cas Number:
- 007787-93-1
- IUPAC Name:
- 007787-93-1
- Reference substance name:
- Dichloro(3-chloropropyl)methylsilane
- EC Number:
- 232-136-3
- EC Name:
- Dichloro(3-chloropropyl)methylsilane
- Cas Number:
- 7787-93-1
- Molecular formula:
- C4H9Cl3Si
- IUPAC Name:
- dichloro(3-chloropropyl)methylsilane
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- other: White Russian
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Møllegaard Breeding/Research Centre Ltd, Skensved, DENMARK
- Age at study initiation: not stated
- Weight at study initiation: 2.6 kg
- Diet: standard diet ad libitum
- Water: drinking water ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +/-3
- Humidity (%): 30-70
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12 h/12 h
IN-LIFE DATES: From: 1997-05-27
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml - Duration of treatment / exposure:
- 1.5 minutes
- Observation period:
- None following initial observation.
Severity of findings led to the humane killing of the experimental animal. - Number of animals:
- 1
- Details on study design:
- TEST SITE
- Area of exposure: 6 cm2
- Type of wrap if used: semi-occlusive
REMOVAL OF TEST SUBSTANCE
- Washing (if done): careful wiping
- Time after start of exposure: 2 minutes
SCORING SYSTEM: as in OECD 404
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 2 minutes
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- other: not determined
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 2 minutes
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- other: not determined
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Remarks on result:
- other: severe erythema was observed at 2 min post-exposure. No further measurements were taken.
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Remarks on result:
- other: severe edema was observed at 2 min post-exposure. No further measurements were taken.
- Irritant / corrosive response data:
- 1.5 minute exposure in one animal casued evere erythema and oedema with marked necrosis after 2 minutes.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1A (corrosive) based on GHS criteria
- Conclusions:
- A reliable study, conducted according to OECD 404 and GLP found the neat test material to be corrosive when in semi-occluded contact for 1.5 minutes.
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