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EC number: 606-376-8 | CAS number: 197721-70-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Oral: (Rat-Wistar, GLP, OECD TG 423): LD50 > 2000 mg/kg
[Schering AG, Report No. B060; 1999-02-22]
Dermal (Rat-Wistar, GLP, OEDD TG 402 & 404): LD50 > 2000 mg/kg
[Nihon Schering KK, Report No A11512, 2004-06-18]
Key value for chemical safety assessment
Additional information
The single oral administration of ZK 90965 to male and female Wistar rats was well tolerated with only minor clinical signs immediately after administration in one male. No other clinical signs and effects on body weight were observed. Acute oral toxicity (LD50) of ZK 90965 in Wistar rats is above 2000 mg/kg.
The single dermal administration of ZK 90965 to male and female Spraque Dawley rats was well tolerated without compound-related findings on clinical signs, body weight, and gross pathology. Acute dermal toxicity (LD50) of ZK 90965 in rats is above 2000 mg/kg. No skin irritative or corrosive potential of ZK 90965 was observed.
Justification for classification or non-classification
Not classified according to EEC criteria since LD50 > 2000 mg/kg after oral and dermal administration
Category 5 for oral and dermal administration according to GHS criteria since LD50 > 2000 mg/kg
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