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Diss Factsheets
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EC number: 939-618-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
An OECD TG 201 guideline study in compliance with GLP with freshwater algae (Desmodesmus subspicatus) is available for the test substance. Algae were exposed to nominal concentrations of 1.0 and 3.2 mg/L and WAFs prepared at loading rates of 10, 32 and 100 mg/L under static conditions for 72 hours. Because the test material is volatile, testing was conducted in airtight closed test vessels in order to minimise possible losses due to volatilisation. At the start of the test, the actual test concentrations were 0.81, 2.3, 7.7, 23 and 35 mg/L for the concentrations prepared at 1.0, 3.2, 10, 32 and 100 mg/L, respectively. The measured concentrations decreased to 10-17% of initial after 24 hours and further to 1.7-5.5% of initial after 48 hours of exposure. Based on these results, the Time Weighted Average (TWA) exposure concentrations were calculated. The TWA concentrations corresponded with 0.19, 0.49, 1.4, 4.5 and 7.1 mg/L, respectively.
Reduction of growth rate gradually increased with increasing TWA concentration from 1.4% at the lowest to 43% at the highest concentration. Statistically significant reduction of growth rate was found at test concentrations of 0.49 mg/L and higher. Inhibition of yield increased with increasing TWA concentration of the test substance from 0.19 mg/L upwards resulting in 83% inhibition at a TWA concentration of 7.1 mg/L. Statistically significant inhibition of yield was found at TWA concentrations of 0.49 mg/L and higher. Microscopic observations at the end of the test revealed a normal and healthy appearance of the exposed cells when compared to the control. Based on these data, the 48 -h EC50 values for growth and yield were determined to be >7.1 mg/L and 2.0 (95% C.L: 0.86 -4.8 mg/L), respectively. The 48-h ErC10 and EyC10 values were determined at 1.5 mg/L and 0.27 mg/L, respectively. The 48-h NOEC finally, is 0.19 mg/L for both endpoints. The validity criteria were not met in this study as the pH in various solutions during both the combined limit/range-finding and the final test increased with more than 1.5 units and above 9.0 at the end of the test. The increase was due to the volatility of the test substance and the consequence of testing in a closed system. Despite the addition of extra NaHCO3 and the adjustment of the pH of the test medium before the study it proved not possible to maintain the pH. However, algal growth met the criterion of at least a 16-fold increase. Altogether, the study integrity considered to be not adversely affected by the deviation.
Key value for chemical safety assessment
- EC10 or NOEC for freshwater algae:
- 1.5 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.