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EC number: 208-797-9 | CAS number: 542-05-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Based on the available information, it can be concluded that the chemical 3-oxoglutaric acid shall not exhibit acute toxicity by the oral, inhalation and dermal route (within the concentration values mentioned in the respective end points)
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The target chemical 3-oxoglutaric acid and the read across chemical belong to the same category; that of “dicarboxylic acid”. Both the chemicals share physico-chemical properties within an acceptable range as well as environmental fate properties and aquatic toxicity properties thereby qualifying for suitable read-across. In general, the most striking pattern across the two chemicals is their low toxicity profile.
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from RTECS database
- GLP compliance:
- not specified
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Doses:
- 2750 mg/kg
- Control animals:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 750 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Behavioral - tremor Gastrointestinal - gastritis Gastrointestinal - hypermotility, diarrhea
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Acute toxicity via oral route in rat for glutaric acid is LD50: 2750 mg/kg
- Executive summary:
Acute toxicity via oral route in rat for glutaric acid is LD50: 2750 mg/kg
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 750 mg/kg bw
- Quality of whole database:
- Weight of evidence approach has been used (using predicted value of target as well as available information from read-across substance). The LD50 values in all the case are well above the values that would indicate acute toxicity by the oral route.
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Species:
- rat
- Strain:
- Wistar
- Sex:
- not specified
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- nose/head only
- Vehicle:
- not specified
- Duration of exposure:
- 7 h
- Sex:
- not specified
- Dose descriptor:
- LC0
- Effect level:
- 5.7 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 7 h
- Remarks on result:
- other: Sex details not given
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LC0 value of 3-oxoglutaric acid for 7h in Rat (Wistar ) was estimated to be 5.69mg/L air . This value indicates that 3-oxoglutaric acid does not exhibits acute toxicity by the inhalative route.
- Executive summary:
The LC0 value of 3-oxoglutaric acid for 7h in Rat (Wistar ) was estimated to be 5.69mg/L air . This value indicates that 3-oxoglutaric acid does not exhibits acute toxicity by the inhalative route. The LC0 value of 5.69 mg/L indicates that there is no adverse effect on any of the test population and in the absence of any available experimental data, this prediction is considered to be a useful pointer that the chemical 3 -oxoglutaric acid is not expected to exhibit acute toxicity by the inhalation route
Reference
The prediction was based on dataset comprised from the following descriptors: LC0
Estimation method: Takes average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
((((("a" and ("b" and ( not "c") ) ) and "d" ) and "e" ) and ("f" and ( not "g") ) ) and ("h" and "i" ) )
Domain logical expression index: "a"
Similarity boundary:Target: C(=O)(O)CC(=O)CC(=O)O
Threshold=50%,
Dice(Atom pairs)
Domain logical expression index: "b"
Referential boundary: The target chemical should be classified as No alert found by Protein binding by OASIS v1.1
Domain logical expression index: "c"
Referential boundary: The target chemical should be classified as Michael addition OR Michael addition >> Michael addition on conjugated systems with electron withdrawing group OR Michael addition >> Michael addition on conjugated systems with electron withdrawing group >> alpha,beta-carbonyl compounds with polarized double bonds by Protein binding by OASIS v1.1
Domain logical expression index: "d"
Referential boundary: The target chemical should be classified as Low (Class I) by Toxic hazard classification by Cramer (original)
Domain logical expression index: "e"
Referential boundary: The target chemical should be classified as Low (Class I) by Toxic hazard classification by Cramer (with extensions)
Domain logical expression index: "f"
Referential boundary: The target chemical should be classified as H-acceptor-path3-H-acceptor by in vivo mutagenicity (Micronucleus) alerts by ISS
Domain logical expression index: "g"
Referential boundary: The target chemical should be classified as No alert found by in vivo mutagenicity (Micronucleus) alerts by ISS
Domain logical expression index: "h"
Parametric boundary:The target chemical should have a value of log Kow which is >= -3.81
Domain logical expression index: "i"
Parametric boundary:The target chemical should have a value of log Kow which is <= 0.571
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- The predicted LD0 value was obtained as 5.699 mg/L air. This value indicates that there is no adverse effect on any of the test population and in the absence of any available experimental data, this prediction is considered to be a useful pointer that the chemical 3 -oxoglutaric acid is not expected to exhibit acute toxicity by the inhalation route.
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Duration of exposure:
- unspecified
- No. of animals per sex per dose:
- no data
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 714.286 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral median lethal dose (LD50) of 3-oxoglutaric acid in rabbit via dermal route was estimated to be 2714.2 mg/kg bw and based on this value it can be estimated that the 3-oxoglutaric acid is not toxic substance via dermal route below the above mentioned dose.
- Executive summary:
The acute oral median lethal dose (LD50) of 3-oxoglutaric acid in rabbit via dermal route was estimated to be 2714.2 mg/kg bw and based on this value it can be estimated that the 3-oxoglutaric acid is not toxic substance via dermal route below the above mentioned dose.
Reference
The prediction was based on dataset comprised from the following descriptors: LD50
Estimation method: Takes average value from the 6 nearest neighbours
Domain logical expression:Result: In Domain
((("a" and ("b" and ( not "c") ) ) and ("d" and ( not "e") ) ) and ("f" and "g" ) )
Domain logical expression index: "a"
Referential boundary: The target chemical should be classified as Acid, aliphatic attach [-COOH] AND Alcohol, olefinic attach [-OH] AND Aliphatic Carbon [CH] AND Aliphatic Carbon [-CH2-] AND Carbonyl, aliphatic attach [-C(=O)-] AND Miscellaneous sulfide (=S) or oxide (=O) AND Olefinic carbon [=CH- or =C<] by Organic functional groups (US EPA)
Domain logical expression index: "b"
Referential boundary: The target chemical should be classified as No alert found by Protein binding by OASIS v1.1
Domain logical expression index: "c"
Referential boundary: The target chemical should be classified as SN2 OR SN2 >> Interchange reaction with sulphur containing compounds OR SN2 >> Interchange reaction with sulphur containing compounds >> Thiols and disulfide compounds by Protein binding by OASIS v1.1
Domain logical expression index: "d"
Referential boundary: The target chemical should be classified as No alert found by Carcinogenicity (genotox and nongenotox) alerts by ISS
Domain logical expression index: "e"
Referential boundary: The target chemical should be classified as Structural alert for nongenotoxic carcinogenicity OR Substituted n-alkylcarboxylic acids (Nongenotox) by Carcinogenicity (genotox and nongenotox) alerts by ISS
Domain logical expression index: "f"
Parametric boundary:The target chemical should have a value of log Kow which is >= -2.76
Domain logical expression index: "g"
Parametric boundary:The target chemical should have a value of log Kow which is <= -0.647
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 714.28 mg/kg bw
- Quality of whole database:
- In the absence of any experimental data, the predicted data as well as the available data is considered to be a useful pointer that the chemical 3 -oxoglutaric acid is not expected to exhibit acute toxicity by the dermal route.
Additional information
Based on the available information, it can be concluded that the chemical 3-oxoglutaric acid shall not exhibit acute toxicity by the oral, inhalation and dermal route (within the concentration values mentioned in the respective end points)
Justification for selection of acute toxicity – oral endpoint
Weight of evidence approach has been used rather than a single study
Justification for selection of acute toxicity – inhalation endpoint
Model considered relaible by OECD
Justification for selection of acute toxicity – dermal endpoint
Model considered relaible by OECD
Justification for classification or non-classification
Based on the available information, it can be concluded that the chemical 3-oxoglutaric acid shall not exhibit acute toxicity by the oral, inhalation and dermal route (within the concentration values mentioned in the respective end points). Thus, for the classification, the chemical is not considered to be classifed for acute oral, inhalation and dermal toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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