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EC number: 211-745-8 | CAS number: 693-21-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Short description of key information on bioaccumulation potential result:
Evaluation of toxicokinetics of the substance Diethyleneglycol dinitrate - CAS No. 693-21-0 was performed according to the demand given in part 8.8.1 of Annex VIII to the Directive (EC) No. 1907/2006 (REACH) : “Assessment of the toxicokinetic behavior of the substance to the extent that could be derived from the relevant available information”.
The evaluation of toxicokinetics is based on information from three sources:
- Experimental data of toxicological tests
- Literature data obtained from internet
- Data from toxicological databases – free and commercial
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
The substance DEGDN is not absorbed through the skin. After oral or inhalation exposure it is fairly quickly absorbed and systemically distributed through the body (hours). Through the blood circulation it reaches and influences the heart, CNS, liver and kidneys, etc.
In the body the nitrate form is converted to nitrite form which causes the most of symptoms observed after exposition. It seems that the elimination through the kidneys to the urine takes several days after both the lower and higher doses.
Discussion on bioaccumulation potential result:
Probable Routes of Human Exposure
Occupational exposure to Diethylene glycol dinitrate may occur through dermal contact with this compound at workplaces where diethyleneglycol dinitrate is produced or used. Limited exposure to general population to diethyleneglycol dinitrate may occur via inhalation. In sporadic cases the acute oral poisoning is encountered.
Toxicokinetics Evaluation Summary
The substance is not absorbed through the skin. After oral or inhalation exposure it is fairly quickly absorbed and systemically distributed through the body (hours). Through the blood circulation it reaches and influences the heart, CNS, liver and kidneys, etc.
In the body the nitrate form is converted to nitrite form which causes the most of symptoms observed after exposition. It seems that the elimination through the kidneys to the urine takes several days after both the lower and higher doses.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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