Registration Dossier
Registration Dossier
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EC number: 231-658-9 | CAS number: 7680-73-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: No test guideline followed, inadequate documentation, no indication of purity.
Data source
Reference
- Reference Type:
- publication
- Title:
- Long-term effects of N-methylpyridinium chloride on the target organism
- Author:
- Antonenko T, Nechkina M, Nakoryakova M, Kulikova L & Chomutova T
- Year:
- 1 984
- Bibliographic source:
- Gigiena i Sanitariya (1984), 49(1), 74-75 (publication written in Russian)
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- no data
- GLP compliance:
- no
- Test type:
- other: no data
- Limit test:
- no
Test material
- Reference substance name:
- 1-methylpyridinium chloride
- EC Number:
- 231-658-9
- EC Name:
- 1-methylpyridinium chloride
- Cas Number:
- 7680-73-1
- Molecular formula:
- C6H8ClN
- IUPAC Name:
- 1-methylpyridin-1-ium chloride
- Details on test material:
- - Name of test material (as cited in publication): N-methylpyridinium chloride
- Purity: no data
1-methylpyridinium chloride is a hygroscopic crystalline substance. It mixes well with water and alcohol and does not dissolve in organic solvents.
Remark: The publication mentions, that the technical product is a 85% solution in water. However, based on the used wording, it is a highly probable that the material actually tested was the solid substance.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- no data
- Doses:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- no data
- Statistics:
- no data, however the result is reported with an estimated error range.
Results and discussion
- Preliminary study:
- not applicable
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 260 mg/kg bw
- Based on:
- not specified
- Mortality:
- no data
- Clinical signs:
- other: no data
- Gross pathology:
- no data
- Other findings:
- no data
Any other information on results incl. tables
In the publication, the result was given as 2260 ± 285.3 mg/kg
Applicant's summary and conclusion
- Conclusions:
- In some secondary literature the result of this study is given as LD50: 285 mg/kg. However, based on the original publication, it is obvious that this figure refers to the estimated error and not to the LD50 value itself.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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