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Diss Factsheets
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EC number: 266-104-5 | CAS number: 66069-34-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
A 96 hour acute toxicity to fish study was completed on the surrogate material Potassium Clavulanate according to EU Method C1 from the official journal of the European Communities. The test was conducted under static conditions. No mortality was observed throughout the study which gave an LC50 value of > 790 mg/L and a NOEC value of 790 mg/L. the measured concentrations were calculated to be 79% of the nominal concentration.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 790 mg/L
Additional information
Two 96 hour acute toxicity to fish studies were conducted on the surrogate material Potassium Clavulanate. Please see our read across proposal in section 13 for further details as to why read across is applicable.
There is not much difference between the two acute fish studies. Both studies have been conducted according to GLP guidelines, both have been conducted at the same laboratory (Brixham Environmental Laboratory, Zeneca Limited). Both studies were tested for 96 hours under static conditions. The major difference between the two studies was that one of the studies was conducted on the rainbow trout and the other study was conducted on the bluegill sunfish. We have selected the study on the bluegill sunfish as the key study because out of the two studies available this was determined to have the worst case result and the lowest EC50 value.
The results of the two studies have been shown below:
POTASSIUM CLAVULANATE: Determination of acute toxicity to bluegill sunfish (Lepomis macrochirus)
A nominal concentration of 1000 mg/L was used for the study. The measured concentrations were calculated to be 79% of the nominal concentrations, which means the 96 hour LC50 was > 790 mg/L and the 96 hour NOEC = 790 mg/L.
Potassium Clavulanate: Determination of acute toxicity to rainbow trout (oncorhynchus mykiss)
The nominal concentration tested within the study was 1000mg/L. The mean measured exposure concentration of the test substance was 96% of the nominal exposure concentration, which has provided the following mean measured results:
The 96 hour LC50 values were determined to be > 960 mg/L-1
The 96 hour NOEC = 960 mg/L-1.
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