Registration Dossier
Registration Dossier
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EC number: 254-879-2 | CAS number: 40306-75-0
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The lethal concentration (LC50) value of 3-acetamido-5-amino-4-hydroxybenzenesulphonic acid in fish[ Pimephales promelas] in a 96 hr study on mortality effect was found to be 245.685mg/L. Thus, considering the CLP Criteria for aquatic classification of the substance , it is concluded that 3-acetamido-5-amino-4-hydroxybenzenesulphonic acid shall not exhibit short term toxicity to fish ( Pimephales promelas ).
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 245.685 mg/L
Additional information
The lethal concentration (LC50) value of phthalylsulfathiazole in fish (Pimephales promelas) in a 96 hr study on mortality effect was estimated to be 245.685mg/L. The supporting studies also predicted an LC50 value above 100 mg/L as has been mentioned in the table attached below;
Sr. No |
Endpoint name |
Value |
Units |
Species |
1 |
LC50 | 245.685 | mg/l | Pimephales promelas |
| 2 | LC50 | 152.0679 | mg/l | Oncorhynchus mykiss |
| 3 | LC50 | 147.8293 | mg/l | Lepomis macrochirus |
As can be observed from the above information, the endpoint varies from 147.8293 to 245.685 mg/L. Thus, all the LC50 values are above 100 mg/L, so indicating that no aquatic toxicity to the fishes by 3-acetamido-5-amino-4-hydroxybenzenesulphonic acid will be applicable. Therefore it can be concluded that the substance is not classified as per the CLP criteria for fish toxicity.
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