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EC number: 271-729-1 | CAS number: 68606-18-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
No effects up to the limit of water solubility (WS 0.05 mg/L)
Key value for chemical safety assessment
Additional information
No experimental data evaluating the acute toxicity of Glycerides, mixed coco, decanoyl and octanoyl (CAS No. 68606-18-8) to fish species are available. Therefore, toxicity data from analogue category members, propane-1,2,3-triyl trisheptanoate (CAS No. 620-67-7), 1,2,3-propanetriyl trioleate (CAS No. 122-32-7) and Glycerides,C14-18 and C16-18 unsaturated, mono-, di- and tri- (CAS No. 91052-28-7), are used as read-across in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Glycerides, mixed coco, decanoyl and octanoyl is mainly a triglyceride formed by the combination of fatty acids of different C-chain lengths (C6 to C18 unsaturated) and glycerol. Propane-1,2,3-triyl trisheptanoate (CAS No. 620-67-7) and 1,2,3-propanetriyl trioleate (CAS No. 122-32-7) are also triglycerides with fatty acid chain lengths of C7 and C12 to C18 unsaturated respectively. For Glycerides,C14-18 and C16-18 unsaturated, mono-, di- and tri- (CAS No. 91052-28-7) the triester content is lower than for the other three substances (up to 15%), with a predominant monoester content. The lower degree of esterification might have an effect in the bioavailability to aquatic organisms, due to a reduced size of the molecules, the potential to cross biological membranes is expected to increase. Therefore, Glycerides,C14-18 and C16-18 unsaturated, mono-, di- and tri- can be regarded as a worst-case read-across substance.The behaviour of these four substances in the water phase is expected to be very similar based on low water solubility values (< 0.05 mg/L for all) and log Pow (> 4). The three read-across substances cover the whole fatty acid C-chain range present in Glycerides, mixed coco, decanoyl and octanoyl. Therefore, they are considered to give a reliable indication of the toxicity of this substance to aquatic organisms, and the read-across is justified.
One study evaluating the acute toxicity of propane-1,2,3-triyl trisheptanoate (CAS No. 620-67-7) to fish is available (Scholz, 1994). This test was conducted according to EU Method C1, under GLP conditions. Fish (Danio rerio) were exposed to the test substance for 96 hours within a semi-static water regime at a nominal concentration of 10,000 mg/L. After 96 hours exposure, no mortality was observed in either treatment or control groups. Therefore, the LC50 (96 h) was determined to be > 95 mg/L (nominal concentration) and > 64 mg/L (measured concentration). The determination of measured test concentrations was performed by DOC (Dissolved Organic Carbon) analysis, which is more suitable for substances with higher water solubility. The high reported measured concentration (64 mg/L) despite the low water solubility of the substance (< 0.05 mg/L) shows that probably other constituents from the solution have been accounted for as test substance. Nevertheless, since no effects were observed it can be stated that no acute toxicity to fish within the range of the water solubility of propane-1,2,3-triyl trisheptanoate is expected. The study conducted with Glycerides, C14-18 and C16-18 unsatd. mono-, di- and tri- (CAS No. 91052-28-7) follows the German national Guideline DIN 38412/15 (Examination of water, waste water and sludge; bioassays (L); determination of the effect of substances in water on fish- Fish test (L15)). In this static test, fish (Leuciscus idus) were exposed to the test substance for 48 hours. After this period, no mortality or any other effects were reported at any of the concentrations tested (LC50 (48 h) > 10000 mg/L). The study available for 1,2,3-propanetriyl trioleate (CAS No. 122-32-7)(Bogers, 1988) was conducted according to the German Method Evaluation of hazardous substances in water- Determination of the acute toxicity to Fish, under GLP conditions. Fish (Cyprinus carpio) were exposed to the test substance within a static water regime at 23 ± 2°C. During the exposure period, no mortality was observed in treatment or control groups. The LC50 (48 h) was determined to be > 1000 mg/L (nominal concentration).
Based on the results obtained for the structurally related category members (in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5), no acute toxicity of Glycerides, mixed coco, decanoyl and octanoyl (CAS No. 68606-18-8) to fish species up to the limit of its water solubility (< 0.05 mg/L) is expected.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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