2-Propenoic acid, γ-ω-perfluoro-C8-14-alkyl esters

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1985-09-30 to 1985-10-14

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1985

Report date:

1985

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Perfluoroalkylethylacrylate

IUPAC Name:

Perfluoroalkylethylacrylate

Constituent 2

Reference substance name:

2-Propenoic acid, γ-ω-perfluoro-C8-14-alkyl esters

EC Number:

288-003-5

EC Name:

2-Propenoic acid, γ-ω-perfluoro-C8-14-alkyl esters

Cas Number:

85631-54-5

Molecular formula:

C11H7F13O2 - C17H7F25O2

IUPAC Name:

3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl prop-2-enoate; 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl prop-2-enoate; 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,12-henicosafluorododecyl prop-2-enoate; 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,13,13,14,14,14-pentacosafluorotetradecyl prop-2-enoate

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Doses:

2000 mg/kg bw

No. of animals per sex per dose:

5

Control animals:

no

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Mortality:

none

Applicant's summary and conclusion

Interpretation of results:

other: not classified according to the CLP Regulation (EC 1272/2008)

Conclusions:

Based on the results of this study the LD50 is greater 2000 mg/kg bw.

Executive summary:

The purpose of this study was to assess the acute toxicity of the test substance when administered by oral gavage to rats, followed by an observation period of 14 days. A single dose of 2000 mg/kg bw test substance was administered to the rats (5 per sex). All animals were examined for clinical signs within the first 30 minutes and approximately 1, 2, 3 and 6 hours after treatment on day 1 and once daily during test days 2-14. No intercurrent deaths occurred during the course of the study. All animals gained body weight during the observation period. Some unspecific clinical signs (i.e. hunch posture, spontane activity reduced and stilted gait) were observed within the first 4 hours. Thereafter, all animals were free of any clinical singn until the end of the observation period of 14 days. All animals were killed at the end of the observation.

Based on the results of this study the LD50 is greater than 2000 mg/kg bw.