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EC number: 243-039-0 | CAS number: 19406-86-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2000 -2001
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: study was carried out according to test guidline OECD401 and under GLP-conditions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3-amino-p-toluamide
- EC Number:
- 243-039-0
- EC Name:
- 3-amino-p-toluamide
- Cas Number:
- 19406-86-1
- Molecular formula:
- C8H10N2O
- IUPAC Name:
- 3-amino-p-toluamide
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Strain: HSD: Sprague Dawley SD
- Source: HARLAN WINKELMANN, SPF breeding stock
- Weight at study initiation: male: 188 - 206g (average 197g); female: 168 - 187g (average 179g)
- Age at start of study: 6 - 10 weeks
- Fasting period before study: from about 16 hours before to 3 - 4 hours after treatment
- Housing: in fully air-conditioned rooms in macrolon cages (type 4) on soft wood granulate in groups of 5 animals
- Food: ssnif(8l R/M-H (V 1534), ad libitum
- Water: tap water in plastic bottles, ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Remarks:
- de-ionized
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 20 % - Doses:
- 1250, 1600, 2000 mg/kg bw (males only 2000 mg/kg bw)
- No. of animals per sex per dose:
- 5 females; 5 males only in case of 2000 mg/kg bw
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of body weighing: 1/week
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, necropsy
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 727 mg/kg bw
- Based on:
- test mat.
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: no lethality of any of the 5 male rats
- Mortality:
- Females: 1 of 5 at 1250 mg/kg bw, 1 of 5 at 1600 mg/kg bw, 4 of 5 at 2000 mg/kg bw; lethality occurred up to day five of the study.
Males: none detected - Clinical signs:
- other: Unspecific symptoms the animals showed impairments of motility, respiration and consciousness. Additionally prone position, crawling forward, stupor and narrowed palpebral fissure were observed sporadically up to day four of the study.
- Gross pathology:
- Necropsy of the decedent animals revealed diffuse reddening of the small intestine
mucosa. The female animal of the 1250 mg/kg body weight dose group, which was
found dead, showed a dark red discolored lung.
The animals killed at the end of the observation period showed no macroscopically
visible changes. - Other findings:
- The animals killed at the end of the observation period showed no macroscopically visible changes .
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 was 1727mg/kg bw after single oral gavage in female rats.
Classification for acute oral toxicity according to EC 1272/2008: H302, Cat. 4 - Executive summary:
Male and female Sprague Dawley were subjected to test acute oral toxicity. The test substance was administered by gavage.
The acute oral toxicity testing of 3 -amino-4-methylbenzamide in the rat yielded the following median lethal dose (LD50): Female animals: 1727 mg/kg body weight. Male animals did not show a higher sensitivity to the test substance.
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