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EC number: 932-051-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
There are GLP guideline oral acute toxicity studies for the reaction product and the two substances that comprise it CAS No. 68411-30-3 sodium 4-undecylbenzenesulfonate and CAS No. 12068-03-0 sodium toluenesulfonate. The LD50 values are 2240, 1080 and >3000 mg/kg bw, respectively in guideline studies. Per EU criteria all three test substances are deemed "practically non-toxic". There is a single dermal study for CAS No. 68411-30-3 sodium 4-undecylbenzenesulfonate. The LD50 value is >2000 mg/kg bw.
In accordance with column 2 of REACH Annex VIII-X, in addition to the oral route, for substances other than gases, an acute toxicity study for at least one other route is required. The choice of the second route depends on the nature of the substance and the likely route of human exposure. As dermal is the most likely route of exposure and acute dermal toxicity data is available, no data gap exists. There is however an inhalation study for a related substance, a hydrotrope similar to one of the read across substances; there was no toxicity observed at the 6.41 mg/L dose over the 231 minute exposure.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 240 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Value:
- mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
There are additional acute oral and dermal toxicity studies for related, read across substances. The results of these supporting studies are consistent with the three key studies. The conclusions from all the studies is that these substances are practically non-toxic.
One inhalation study is a 1980 (non-GLP) acute inhalation study with ammonium xylene sulphonate (CAS No. 26447-10-9) that is a 232-minute, limit test, exposure of male and female rats with no vehicle and a 14-day post exposure observation period. There were no deaths at the 6.41 mg/L dose. Aerosolization was done by a DeVilbiss Nebulizer and exposures were in glass chambers. One of the 10 animals demonstrated clinical signs (soft stool), 2 of the 10 had slight weight gains at days 7 and 14, and 5 of the 10 showed slight mottling or a moderate congestion of lungs at necropsy. The conclusion was reported as "practically nontoxic".
Another inhalation study is conducted with the constituent Benzenesulfonic acid, dodecyl, sodium salt. However, this study is regarded as Klimisch 3. Test substance identity is uncertain and even not representative of LAS; study lacks proper analytical information. No mortality occurred at concentrations up to 260 mg/m3. At 310 mg/m3, one rat died during exposure and 2 rats died one day post exposure. The test material is considered moderately toxic by inhalation. However, it is important to note that this laboratory exposure is not representative of the possible LAS exposure during actual use. Given this lack of relevance to real-world exposure potential, the use of this study for risk assessment purposes is limited.
Justification for classification or non-classification
The available studies with oral, dermal and inhalation exposure demonstrate that the reaction product is of low acute toxicity. No classification is warranted according to EU CLP regulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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