Registration Dossier
Registration Dossier
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EC number: 206-851-6 | CAS number: 383-63-1
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Ethyl trifluoroacetate (TFAE) is a colourless fluid liquid, transparent, with characteristic pleasant odour (purity >=99%), considered to be highly volatile.
By oral route, TFAE may be hydrolysed into ethanol and TFA which is fully miscible in water, where TFA will exist under its ionised form (acetate). Afterwards, TFA dissolved in acidic gastric liquid may be submitted to enteropatic circulation, then distributed in the body via the blood as ionised form considering its distribution coefficient log D (-0.58) and finally excreted mainly in the urine and in the bile (less extent) as parent compound. In other way, considering the acidity of the gastric fluid (i.e. pH =1), it is unlikely that the hydrolysis of TFAE may occur quickly after ingestion. Therefore, in the meantime, TFAE may be systemic absorbed after metabolism in the liver, and then excreted as parent compound or as conjugated metabolites.
Absorption of TFAE may occur after skin contact even if this absorption may be very limited considering the absence of local and systemic effects in the acute dermal toxicity study up to 2011 mg/kg bw and higher, the absence of skin irritation and sensitisation by skin contact.
In any case, if TFAE is dermal absorbed , it may be distributed in the body via the blood where it is likely hydrolised into ethanol and ionised form TFA and finally excreted mainly in the urine and in the bile (less extent) as parent compound.
Considered as highly volatile based on a read-across approach with TFA and TFAH (see 4.6), TFAE vapor may be inhaled at room temperature and then absorbed as such or as TFA and ethanol after hydrolysis of vapour TFAE in the mucus.Then, TFA is distributed in the body via the blood as ionised form considering its distribution coefficient log D (-0.58) and finally excreted mainly in the urine and in the bile (less extent) as TFA.
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