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EC number: 274-446-1 | CAS number: 70214-76-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: test performed according to OECD and GLP guidelines
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Title:
- Unnamed
- Year:
- 2 002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 6,8-dimethylnona-3,5-dien-2-one
- EC Number:
- 274-446-1
- EC Name:
- 6,8-dimethylnona-3,5-dien-2-one
- Cas Number:
- 70214-76-5
- Molecular formula:
- C11H18O
- IUPAC Name:
- 6,8-dimethylnona-3,5-dien-2-one
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test organisms
- Test organisms (species):
- Desmodesmus subspicatus (previous name: Scenedesmus subspicatus)
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 72 h
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 9.3 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 2.5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
Any other information on results incl. tables
-
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Based on these data the nominal median effect concentration with respect to biomass production
(EbC50 (24-72 h) of DIMETHYLNONADIENON to Scenedesmus subspicatus was calculated to be
9.3 mg/l (95 % confidence limits: 7.8-11.0 mg/l).
The no-observed-effect concentration with respect to biomass production (NOEC, EbC0) was 2.5 mg/l.
100 % inhibition (EbC100) was observed at 80 mg/l. - Executive summary:
The median growth inhibiting concentration (ErC50 / EbC50) and the no-effect concentration (ErC0 / EbC0), based on growth rates and cell growth (algal biomass production), of DIMETHYLNONADIENON to the green alga Scenedesmus subspicatus were investigated over a period of 72 h. The nominal concentrations of DIMETHYLNONADIENON were 2.5, 5, 10, 20, 40 and 80 mg~, respectively.
Due to the limited water solubility of the test material the water accommodated fractions were tested. These were prepared by adding the respective concentrations as acetonic stock solutions to the empty glass vessels. After complete evaporation of the solvent the algal medium was added. Following a moderate stirring period for 24 h at room temperature the undissolved materials were removed by sterile filtration (0.45 um) to obtain sterile water accommodated fractions for the algal growth test. No chemical analyses of the test media were conducted.
With respect to algal growth rate inhibition the following effects as compared to the untreated controls were observed: 80 mg/l (99 %), 40 mg/l (88 %), 20 mg/l (46 %), 10 mg/l (15 %). No significant effects «10 % were observed at 5 and 2.5 mg/l.
Based on these data the nominal median effect concentration with respect to growth rate (ErC50 /24-72 h) of DIMETHYLNONADIENON to Scenedesmus subspicatus was calculated to be 19.8 mg/l (95 % confidence limits: 17.0-22.9 mg/l).
The no-observed-effect concentration with respect to growth rate (NOEC, ErC0) was 5 mg/l. 100 % inhibition (ErC100) was observed at 80 mg/l.
With respect to algal cell growth inhibition (biomass production) the following effects as compared to the untreated controls were observed:
80 mg/l (101 %),40 mg/l (99 %), 20 mg/l (87 %), 10 mg/l (56 %), 5 mg/l (16 %). No significant effects «10 % were observed 2.5 mg/l.
Based on these data the nominal median effect concentration with respect to biomass production (EbC50 / 24-72 h) of DIMETHYLNONADIENON to Scenedesmus subspicatus was calculated to be 9.3 mg/l (95 % confidence limits: 7.8-11.0 mg/l). The no-observed-effect concentration with respect to biomass production (NOEC, EbC0) was 2.5 mg/l. 100 % inhibition (EbC100) was observed at 80 mg/l.
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