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Diss Factsheets
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EC number: 606-870-3 | CAS number: 219715-34-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Oral:
An acute oral toxicity test (Up and Down Procedure) was conducted with rats to determine the potential for M-TMP to produce toxicity from a single dose via the oral route. Under the conditions of this study, the acute oral LD50 of the test substance was estimated to be 1,750 mg/kg of body weight in female rats with an approximate 95% confidence interval of 651.9 mg/kg (lower) to 2,690 mg/kg (upper).
Dermal:
An acute dermal toxicity test was conducted with rats to determine the potential for M-TMP to produce toxicity from a single topical application. Under the conditions of this study, the single dose acute dermal LD50 of the test substance was greater than 5,000 mg/kg of body weight in male and female rats.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 1 750 mg/kg bw
Additional information
Oral:
The key study for acute oral toxicity was conducted in accordance with U.S. EPA. Health Effects Test Guidelines, OPPTS 870.1100 (2002). The study was conducted in line with GLP. A reliability rating of 1 according to the criteria of Klimisch, 1997.
Dermal:
Key value = >5000 mg/kg
The key study for acute oral toxicity was conducted in accordance with U.S. EPA. Health Effects Test Guidelines, OPPTS 870.1200 (Acute Dermal Toxicity). The study was conducted in line with GLP. A reliability rating of 1 according to the criteria of Klimisch, 1997.
Justification for classification or non-classification
Oral:
For acute toxicity via the oral route, according to regulation EC No. 1272/2008, the substance should be classified as Category 4 H302 (Harmful if swallowed) with the signal word "Warning". According to directive 67/458/EEC, the substance should be classified as Xn; R22 (Harmful if swallowed).
Dermal:
The key parameter chosen for acute toxicity for the dermal route was greater than the criteria set out in Directive 67/548/EEC and also Regulation (EC) no 1272/2008, therefore classification for acute toxicity was not considered to be necessary.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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