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EC number: 220-877-5 | CAS number: 2923-16-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
READ-ACROSS JUSTIFICATION
When environmental data required by REACH regulation are missing for TFAK, a read-across approach with Sodium trifluoroacetate (TFANa, CAS RN: 2923-18-4) is performed. This approach is justified by the information below:
1) Structural similarity
Both substances are trifluoroacetate salts and therefore have similar chemical structure. The only difference between two substances is the cation which is potassium for TFAK and Sodium for TFANa. As potassium and sodium are not toxic to the aquatic organisms, the toxicity effect of TFAK and TFANa should be the activity of the trifluoroacetate moiety. This supports the fact that they should show similar effect on organisms.
2) Similar bioavailability
Both substances are solid very soluble in water (water solubility at 25°C of 625 g/L for TFANa and 697 g/L for TFAK). They have a low volatility (Vapour pressure at 25°C of 10E-5 Pa for TFANa (QSAR) and < 10E-4 Pa for TFAK) and a low potential of bioaccumulation (LogKow values of -3.31 for TFANa (QSAR) and -3.12 for TFAK).
In the aquatic environment, both substances ionized into the trifluoroacetate anion and the K and Na cations. Therefore, the bioavailability of the trifluoroacetate moiety should be the same for both substances. Additionally, as the degradability of the cations K and Na is not applicable, the degradability of the trifluoroacetate moiety should be take into account to assess the degradability of TFAK and TFANa.
Based on the above information, both substances should show similar bioavailability to organisms in the environment, and similar fate and behaviour in and between the environmental compartments.
3) Similar ecotoxicity potential
Data on aquatic toxicity of TFAK is only available for Daphnids. The 48-hour EC50 for Daphnia magna is >100 mg/L (Study performed in 2000) and no immobility has been observed in this study. Acute toxicity data on the same species,Daphnia magna, is available for TFANa, and the 48-hour EC50 was higher than 1200 mg/L and no immobility has been observed in this study. This suggests that both substances should have similar toxicity to the aquatic organisms.
To conclude, based on the similar chemical structure, bioavailability and ecotoxicity potential, the ecotoxicity data and degradation information obtained on TFANa can be used to assess the environmental profile of TFAK. Data on TFANa are reported in the REACH registration dossier of trifluoroacetic acid (CAS RN: 76-05-1), submitted by the same registrant as the present dossier. In order to avoid repeating all data and information on TFANa, which can make the read-across approach difficult to understand, only key studies obtained on TFANa are reported in the read-across approach in the present dossier for TFAK.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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