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Diss Factsheets
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EC number: 200-261-2 | CAS number: 56-18-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation, other
- Remarks:
- in vivo study already available
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented study report which meets basic scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Principles of method if other than guideline:
- Method according to the Federal Register, Vol . 38, No. 187 (27.09.73), § 1500 .42 and Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics, FDA, Austin, Texas 1959, p .51
- GLP compliance:
- no
Test material
- Reference substance name:
- 3,3'-iminodi(propylamine)
- EC Number:
- 200-261-2
- EC Name:
- 3,3'-iminodi(propylamine)
- Cas Number:
- 56-18-8
- Molecular formula:
- C6H17N3
- IUPAC Name:
- bis(3-aminopropyl)amine
- Details on test material:
- - Analytical purity: 99%
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: M. GAUKLER (6050 Offenbach)
- Weight at study initiation: 2.56 kg
- Diet: Ssniff K, standard diet for rabbits and guinea pigs (INTERMAST GMBH, Soest), ad libitum
- Water: ad libitum
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 100 µl - Duration of treatment / exposure:
- single application
- Observation period (in vivo):
- 8 d
- Number of animals or in vitro replicates:
- 6 (3 males, 3 females)
- Details on study design:
- SCORING SYSTEM: Follows OECD guideline 405
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24 h - 8 d
- Score:
- 3 - 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: opacity of the cornea could not be scored after 72 h due to severe ulcerations
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24 h -8 d
- Score:
- 0 - 1
- Max. score:
- 2
- Reversibility:
- not reversible
- Remarks on result:
- other: changes in the iris could not be scored after 72 h due to severe ulcerations
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24 h - 8d
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- not reversible
- Remarks on result:
- other: redness of the conjuctivae could not be scored after 72 h due to severe ulcerations
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24 h - 8 d
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritant / corrosive response data:
- In 2 out of 6 animals after 72 h and all animals after 8 d severe ulcerations were observed. Further oberservations were: grey/white nictating membrane, sticky eyes, severe suppuration, grey/white mucous membrane, blood.
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information
- Conclusions:
- Based on the findings of the study Dipropylenetriamine was judged corrosive to the eyes.
- Executive summary:
Dipropylenetriamine was applied to conjunctival sac of the eyes of 6 Vienna White rabbits. Animals were observed after 24, 48 and 72 hours and up to 8 days after the treatment. The application caused corrosion (irreversible), predominantly expressed by severe corneal opacity.
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