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EC number: 203-635-3 | CAS number: 108-98-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2001
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 211 (Daphnia magna Reproduction Test)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Benzenethiol
- EC Number:
- 203-635-3
- EC Name:
- Benzenethiol
- Cas Number:
- 108-98-5
- Molecular formula:
- C6H6S
- IUPAC Name:
- benzenethiol
- Details on test material:
- - Name of test material : benzenthiol
- Molecular formula : C6H6S
- Molecular weight : 110.18
- Substance type: liquid (a clear, colorless)
- Analytical purity: >98.0%
The determination of purity and molecular fomula were by IR , NMR and HPLC.
- Lot/batch No.:E99776L
- Storage condition of test material: at room temperature under dark
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
PHYSICO-CHEMICAL PROPERTIES
- Melting point: -14.8℃
- Boiling point: 168℃
- Vapour pressure:0.13kPa (18℃)
- Water solubility (under test conditions): 836mg/L
- log Pow:2.52
- pKa: 6.62
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling method:
volume : 5 mL
sampling point : 0,1,7,8,14,and 15 day
The concentration of the test substance in the samples was determined by GC method.
Test solutions
- Vehicle:
- yes
- Details on test solutions:
- - Method:
(1)A stock solution of 100mg/L of test subsances was prepared at the beginning of the test. A stock solution diluted with M4 medium to 1mg/L .
(2)The positive control was dilution water.
(3)Ten test vessels was prepared each concentrations. Each test vessels were added 80mL of the test solutions.
(4)All test vessels were checked that those appearance.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name:Daphnia magna
- Source:National Institute for Environmental studies
Feeding during test
- Food type:Chlorella vulugaris
- Amount:0.1~0.2mgC/day/one Daphnia magna
ACCLIMATION
- Acclimation period: 28days
- Breeding dencity : 20~50 animals/L test water
- Acclimation conditions :same as test
- Type and amount of food: Chlorella vulugaris
- Ligthting : interior light ,16-hour light/8-hour dark cycle
- Type and amount of food:0.1mg~0.2mgC/day/one Daphnia magna
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Total exposure duration:
- 21 d
- Post exposure observation period:
- no
Test conditions
- Hardness:
- 252mg/L (as CaCO3 ) (M4 medium)
- Test temperature:
- 20±1℃
- pH:
- pH values was measured during the test. It was around pH7.2-7.6 during the test. It was pH7.3 in M4 medium.
- Dissolved oxygen:
- oxygen concentration was measured during the test. It was around 7.5-9.0 (mg/L) during the test.
- Salinity:
- not apparatus
- Nominal and measured concentrations:
- not apparatus
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 100-mL glass vessel
TEST MEDIUM
- Stock culture medium: M4 medium
following composition:
----------------------------
H3BO3: 2.860 mg/l
MnCl2.4H2O: 0.361 mg/l
LiCl: 0.306 mg/l
RbCl: 0.071 mg/l
SrCl2.6H20: 0.152 mg/l
NaBr: 0.016 mg/l
Na2MoO4.2H2O: 0.063 mg/l
CuCl2.2H2O: 0.017 mg/l
ZnCl2: 0.013 mg/l
CoCl2.6H20: 0.010 mg/l
KI: 0.00325 mg/l
Na2SeO3: 0.00219 mg/l
NH4VO3: 0.00058 mg/l
Na2EDTA.2H20: 2.5 mg/l
FeSO4.7H2O: 0.996 mg/l
MgSO4.7H2O: 123.3 mg/l
KCl: 5.8 mg/l
NaHCO3: 64.8 mg/l
NaNO3: 0.274 mg/l
KH2PO4: 0.143 mg/l
K2HPO4: 0.184 mg/l
Thiamine hydrochloride: 0.075 mg/l
Cyanocobalamine(V.B12): 0.001 mg/l
D(+)Biotin(V.H): 0.00075 mg/l
CaCl2.2H2O: 293.8 mg/l
Na2SiO3.9H2O: 10.0 mg/l
-------------------------------------
RANGE-FINDING STUDY
- Results used to determine the conditions for the definitive study: 48hr-EiC50 =0.0044mg/L
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 21 d
- Dose descriptor:
- LC50
- Effect conc.:
- >= 3.3 µg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 21 d
- Dose descriptor:
- EC50
- Effect conc.:
- < 3.7 µg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Remarks on result:
- other: 95% (<4.6%)
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- < 2 µg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- other:
- Duration:
- 21 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 3.3 µg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- other:
- Details on results:
- see attached document.
- Reported statistics and error estimates:
- Statistical methods: Bartlett's test, ANOVA, Dunnett's test,
EC50, LC50 and NOEC were calculated by probit analysis, using the program Probit.
Any other information on results incl. tables
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.