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Reaction mass of Cuprate(4-), [4,5-dihydro-4-[[8-hydroxy-7-[[2-hydroxy-5-methoxy-4-[[2-(sulfooxy)Vinyl]phenyl]azo]-6-sulfo-2-naphthalenyl]azo]-5-oxo-1-(4-sulfophenyl)-1H-pyrazole-3-carboxylato(6-)], trisodium salt and Cuprate(4-), [4,5-dihydro-4-[[8-hydroxy-7-[[2-hydroxy-5-methoxy-4-[[2-(sulfooxy)ethyl]sulfonyl]phenyl]azo]-6-sulfo-2-naphthalenyl]azo]-5-oxo-1-(4-sulfophenyl)-1H-pyrazole-3-carboxylato(6-)]-, sodium and Cuprate(4-), [4,5-dihydro-4-[[8-hydroxy-7-[[2-hydroxy-5-methoxy-4-[2-(sulfooxy)Ethanol]phenyl]azo]-6-sulfo-2-naphthalenyl]azo]-5-oxo-1-(4-sulfophenyl)-1H-pyrazole-3-carboxylato(6-)], trisodium salt
EC number: 941-883-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation assays in vivo in rabbits: non irritant.
Eye irritation assays in vivo in rabbits: non irritant.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin and eye irritation studies on test substance were not available. Therefore, a read-across approach was followed and available studies on RA Substance 01 and RA Substance 02 were used in the assessment.
In particular, RA Substance 01 is a copper complex and shares most of its structure with target substance (all 3 constituents) except for a small portion, which may possibly be released upon cleavage of an azo bond. RA Substance 02 was used to account for possible effects caused by this portion, based on its structural similarity.
A detailed description of the read across approach is attached in section 13.
As for dermal application, two available studies on rabbits exposed to RA Substance 01 reported no evidence of erythema or oedema 24, 48, and 72 hours after patch removal upon a 4-hour exposure period, except for a barely perceptible erythema in one animal at the 24-hour observation time.
As for eye instillation, available studies with RA Substance 01 on rabbits reported minimal conjuctival irritation in terms of redness and/or chemosis, which resolved by the 72-hour observation period, either in case of rinsed eye or not.
In order to complete the assessment, available data on RA Substance 02 was taken into account. In particular, no sign of skin irritation was found in an in vitro test in human epidermal model and no significant ocular effects were reported in rabbits exposed for 21 days, once daily.
Under the test conditions, during the observation period, RA Substance 01 and RA Substance 02 did not induce systemic toxicity nor mortality.
Justification for classification or non-classification
Based on findings in in vivo / in vitro studies on RA Substance 01 and RA Substance 02, no classification within the CLP Regulation (EC 1272/2008) was applied.
In particular, as for skin irritation, the key study (1983) reported mean scores for erythema and oedema over 24 h, 48 h and 72 h below the threshold for classification, i.e. 2.3, in all animals tested.
As for eye irritation, scores averaged over 24, 48 and 72 hours for all animals in the key study (1983) were below the thresholds for classification, i.e. 1 for cornea and iris, and 2 for conjuctivae redness and chemosis.
These findings were confirmed by supporting studies where:
- RA Substance 01 was assessed for skin and eye irritation potential in 2 rabbits;
- RA Substance 02 was tested for skin irritation on human epidermal model and for eye irritation in rabbits upon daily exposure up to 21 days.
On these bases, target substance was considered as non irritant to skin and eye.
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