Registration Dossier
Registration Dossier
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EC number: 273-050-6 | CAS number: 68936-98-1 The complex combination of hydrocarbons produced by the distillation of products from cumene manufacturing process. It consists primarily of diisopropylbenzene with various small amounts of C4 substituted benzenes and heavier non-aromatic hydrocarbons.
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study according to OECD Guideline 431 (adopted 2004)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guideline 431
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- (Laus GmbH)
Test material
- Reference substance name:
- Cumene bottoms (benzene, (1-methylethyl)-, distn. residues)
- IUPAC Name:
- Cumene bottoms (benzene, (1-methylethyl)-, distn. residues)
- Details on test material:
- Batch number 341309
Yeliowish Liquid.
UVCB substance (Benzene, (1-methylethyl)-, distn. Residues)
CAS No 68936-98-1
This substance is an UVCB. Under this definition, no components can be considered as impurities (purity 100%)
Constituent 1
Test animals
- Species:
- other: in vitro model using human-derived epidermal keratinocytes
- Strain:
- other: not applicable
- Details on test animals or test system and environmental conditions:
- highly differentiated model of the human epidermis
Test system
- Type of coverage:
- other: in vitro
- Preparation of test site:
- other: in vitro
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: Deionised water was used as negative control, 8 m KOH was used as positive control
- Amount / concentration applied:
- 50 µL
- Duration of treatment / exposure:
- 3 minutes or 1 hour
- Number of animals:
- For each experiment ("3 minutes" and "1 hour"), two 6-well-plates were used.
Results and discussion
Any other information on results incl. tables
After treatment with the negative control, the absorbance values were well above the required acceptability criterion of mean OD > 0.8 for both treatment intervals. The positive control showed clear corrosive effects for both treatment intervals. After three minutes treatment with the test item, the relative absorbance values were reduced to 98.1 %. This value is well above the threshold for corrosion potential (50%). After one hour treatment, relative absorbance values were increased to 108.8 %. This value is also above the threshold for corrosion potential (15%).
Applicant's summary and conclusion
- Interpretation of results:
- other: not corrosive in human skin model test
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