Octyl (R)-2-(4-chloro-2-methylphenoxy)propionate

Repeated dose toxicity: dermal

Administrative data

Endpoint:

short-term repeated dose toxicity: dermal

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: original study report not available, but secondary source contains sufficient data to assess study as rel. 2

Data source

Reference

Reference 1

Reference Type:

study report

Title:

Unnamed

Year:

1995

Report date:

1995

Reference 2

Reference Type:

secondary source

Title:

Unnamed

Year:

2006

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 410 (Repeated Dose Dermal Toxicity: 21/28-Day Study)

GLP compliance:

yes

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

861229-15-4

Cas Number:

861229-15-4

IUPAC Name:

861229-15-4

Constituent 2

Reference substance name:

Mecoprop-P 2-ethylhexyl ester

IUPAC Name:

Mecoprop-P 2-ethylhexyl ester

Constituent 3

Reference substance name:

MCPP-P 2-EHE

IUPAC Name:

MCPP-P 2-EHE

Constituent 4

Reference substance name:

R-(+)-2-(4-chloro-2-methylphenoxy)-propionic acid, 2-ethylhexyl ester

IUPAC Name:

R-(+)-2-(4-chloro-2-methylphenoxy)-propionic acid, 2-ethylhexyl ester

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Administration / exposure

Type of coverage:

semiocclusive

Vehicle:

unchanged (no vehicle)

Duration of treatment / exposure:

4 weeks (21 applications)

Frequency of treatment:

5 x 6h/week

Doses / concentrations

Remarks:

Doses / Concentrations:
15, 150, 1000 mg/kg bw
Basis:
nominal per unit body weight

No. of animals per sex per dose:

5

Control animals:

other: yes, solvent control: olive oil DAB 10

Details on study design:

Mecoprop-P 2-EHE was applied 5 days per week for 6 hours to the clipped intact dorsal skin (at least 10 % of the body surface area) of Wistar rats over a period of 4 weeks (21 applications) using a semi occlusive dressing.

Results and discussion

Results of examinations

Details on results:

There were no deaths during the study period. No substance-related differences in food consumption were noted during the study.
Body weight gain in test animals was comparable with that seen in controls.
Incidence and types of clinical signs were not adversely affected by treatment.
No skin irritation was observed.
No substance-related changes were observed in the clinical chemistry and haematology results.
No substance-related significantly different mean absolute or relative organ weights were recorded.
No substance-related microscopic findings were recorded.

Effect levels

Dose descriptor:

NOAEL

Effect level:

> 1 000 mg/kg bw/day (nominal)

Sex:

male/female

Basis for effect level:

other: No substance-related findings

Target system / organ toxicity

Critical effects observed:

not specified