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EC number: 610-150-4 | CAS number: 438193-30-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The study was conducted according to the OECD guideline 423 and in compliance with GLP. The substance used for read across (Triphenyl-(4-vinyl)cyclohexyl-methylphospohniumiodid, D 6) is structurally very similar to the registered substance Triphenyl-(4-propenyl)cyclohexyl-methylphosphoniumiodid (E 6). The only difference concerns the length of side chain in para position of the hexylring being a vinyl group for D 6 and a propenyl group for E 6. Therefore a read-across from D 6 to E 6 is considered reliable.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 1171067-76-1
- IUPAC Name:
- 1171067-76-1
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation:approximately 5 weeks at start of acclimatisation
- Weight at study initiation: 205.3 g +/- 16.0 g
- Fasting period before study: the night before administration and 3 hours after administration
- Housing:up to 3 animals/cage
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 6 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21.5-23°C
- Humidity (%): 30-50%
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 0.5% (m/v) solution of Tylose MH 1000
- Details on oral exposure:
- Route of administration: orally, by gavage; using a metal catheter and disposable plastic syringes
Rationale: The acute toxicity is to determine at first by the oral administration.
Form ofadministration: The test item was suspended after crushing with a pestle and mortar to a fine dust shortly before administration in a
0.5 % (m/v) solution of Tylose MH 1000 in deionised water by mixing and continuously mixed by a stirrer during the administration. The
homogeneity was proved visually.
Dose group 2000 mg/kg b.w.: 3 g test item filled up to 15 ml using Tylose solution
Dose group 300 mg/kg b.w.: 0.45 g test item filled up to 15 ml using Tylosesolution
Volume of administration: 1ml / 100 g body weight. Individual doses were adjusted according to the recorded body weight.
Single administration. - Doses:
- Dose groups: 2000 mg/kg body weight (b.w.), 300 mg/kg b.w.
- No. of animals per sex per dose:
- Dose group 2000 mg/kg b.w.: 3 animals
Dose group 300 mg/kg b.w.: 6 animals - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: at 1, 2, 3, 6 and 8 h after dosing and once daily thereafter
- Frequency of weighing: day 0 (prior to dosing), day 7 and day 14
- Necropsy of survivors performed: yes
All animals were examined externally. The cranial, thoracic and abdominal cavities were then
opened and examined macroscopically.
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 300 - < 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- All three animals of the dose group 2000 mg/kg b.w. died within the second hour after administration.
All animals of the dose group 300 mg /kg b.w. survived the 14 day observation period. - Clinical signs:
- The animals responded very quickly to the administration of the test item. The animals of the dose group 2000 mg/kg b.w. showed apathy, coma,
abdominal position and gasping respiration one hour after administration of the test item. These animals died in the course of the following hour.
The animals of the dose group 300 mg/kg b.w. showed only briefly a squatting position two to three hours after administration of the test item. Not
any alterations of the general state of well-being were observed in these animals from six hours after administration. - Body weight:
- The body weight gain of the animals of the dose group 300 mg/kg b.w. was not affected by the administration of the test item.
- Gross pathology:
- In the dead animals of the dose group 2000 mg/kg b.w. a white mushy stomach content ( caused by the test item suspension) and partly severe
atelectatic areas in the lungs were observed. No substance dependent pathological findings were observed in the animals of the dose group
300 mg/kg b.w. The diaphragmatic hernia with a prolapse of a part of the liver into the thorax in one animal is not caused by the test item
administration.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 p.o. rat is therefore > 300 and < 2000 mg/kg b.w.
In accordance with the results of this acute oral toxicity study and in compliance with the criteria of Annex 6 to Directive 2001/59/EU of August 06, 2001 D6 must be classified as harmful (symbol of danger: Xn) and must be Iabelled with R22 "Harmful if swallowed".
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