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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 905-898-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented publication which meets basic scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Dose-Response Studies with Chemical Irritants in the Albino Rabbit 1 Eye as a Basis for Selecting Optimum Testing Conditions for Predicting Hazard to the Human Eye
- Author:
- Griffith JF, et al.
- Year:
- 1 980
- Bibliographic source:
- Toxicology and Applied Pharmacology 55, 501-513 (1980)
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Principles of method if other than guideline:
- Draize Test according to Draize JH, Woodard G and Galvery HO. J. Pharmacol. Exp. Ther. 82:377, 1944. and
CEPA (Corneal Epithelial Plasminogen Activator) Test - GLP compliance:
- no
Test material
- Reference substance name:
- 2,2',2''-nitrilotriethanol
- EC Number:
- 203-049-8
- EC Name:
- 2,2',2''-nitrilotriethanol
- Cas Number:
- 102-71-6
- Molecular formula:
- C6H15NO3
- IUPAC Name:
- 2,2',2''-nitrilotriethanol
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- - Name of test material (as cited in study report): Triethanolamine
- Analytical purity: 98 %
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.01, 0.03, and 0.1 ml.
- Concentration (if solution): unchanged - Duration of treatment / exposure:
- not applicable (eyes were not washed out)
- Observation period (in vivo):
- 21 day
- Number of animals or in vitro replicates:
- 6 per dose
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- fully reversible within: 1 day
- Remarks on result:
- other: 0.01 mL
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 1
- Reversibility:
- fully reversible within: 3 days
- Remarks on result:
- other: 0.03 mL
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 4
- Reversibility:
- fully reversible within: 14 days
- Remarks on result:
- other: 0.1 mL
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- mean
- Time point:
- other: 3, 7 days
- Score:
- 2
- Reversibility:
- fully reversible within: 14 days
- Remarks on result:
- other: 0.1 mL
Any other information on results incl. tables
Rabit eye irritation scores and days to clear with different dose volumes
Maximum Draize score (mean ±SE) Dose (ml) |
Number of days to return to normal Dose (ml) |
||||
0.01 |
0.03 |
0.1 |
0.01 |
0.03 |
0.1 |
0 ± 0 |
1 ± 1 |
4 ± 1 |
1 |
1 |
3 |
Rabbit eye irritation scores at various times after instillation of TEA (Draize score (mean +/- SE)
Test material |
Dose volume |
Number of animals tested |
Day |
Maximum |
Median day to clear |
||||
1 |
3 |
7 |
14 |
21 |
|||||
TEA |
0.01 |
6 |
0 ± 0 |
0 ± 0 |
0 ± 0 |
0 ± 0 |
0 ± 0 |
0 ± 0 |
1 |
0.03 |
6 |
1 ± 1 |
0 ± 0 |
0 ± 0 |
0 ± 0 |
0 ± 0 |
1 ± 1 |
1 |
|
0.10 |
6 |
4 ± 1 |
2 ± 2 |
2 ± 2 |
0 ± 0 |
0 ± 0 |
6 ± 1 |
3 |
* Each value is the average ± SE for 6 animals.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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