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Diss Factsheets
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EC number: 201-837-6 | CAS number: 88-51-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non GLP study according to national standards without analytical test item concentration verification
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: German Industrial Standard Test Guideline DIN 38412
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-amino-4-chloro-5-methyl-benzene sulfonic acid sodium salt
- IUPAC Name:
- 2-amino-4-chloro-5-methyl-benzene sulfonic acid sodium salt
- Details on test material:
- - Name of test material (as cited in study report): Chlor-p-Toluidinsaeure Na-Salz
- Analytical purity: 99.5%
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Great waterflea
- Source: Originally obtained from the Institut national de Recherche Chimique Appliquee, France, since 1978 in-house culture
- Feeding during test: yes
- Food type: green algae culture
- Amount: starting on day 0 of the test with 5.8 mg/L CSB increasing until day 8 to 20 mg/L CSB. Afterwards daily 20 mg/L CSB. Data for a single daphnid parental animal
- Frequency: daily
METHOD FOR PREPARATION AND COLLECTION OF EARLY INSTARS OR OTHER LIFE STAGES: offspring was counted using a particle counter (PC-320 , HIAC). Each particle greater than 350 µm were counted as a daphnid.
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 21 d
Test conditions
- Hardness:
- 2.5 ± 0.25 mM
- pH:
- 7.71 - 8.24
- Dissolved oxygen:
- 7.2 - 9.55 mg/L
- Nominal and measured concentrations:
- nominal: control, 15.625, 31.3, 62.5, 125, 250, 500, 1000 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: glass beakers
- Material, size, headspace, fill volume:glass, 50 mL fill volume
- Renewal rate of test solution (frequency/flow rate): on mondays, wednesdays and fridays
- No. of organisms per vessel: 1
- No. of vessels per concentration (replicates): 10
- No. of vessels per control (replicates): 10
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: dechlorinated and char coal filtered tap water, acidity constant adjusted to 4.3 using H2SO4, hardness adjusted with distilled water
- Ca/mg ratio: 4:1
- Conductivity: 450 - 650 µSiemens/cm
- Intervals of water quality measurement: daily
OTHER TEST CONDITIONS
- Adjustment of pH:
- Photoperiod: 16 : 8 hours light : dark
- Light intensity: 5 - 6 µEinstein (wavelength 400 - 750 nm)
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : survival of parent animals, number of offspring, reproduction rate
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 21 d
- Dose descriptor:
- other: EC0
- Effect conc.:
- 125 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 21 d
- Dose descriptor:
- other: EC0
- Effect conc.:
- 125 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Details on results:
- - Mortality of parent animals: at the highest test concentration of 1000 mg/L 6 out of 10 daphnids
- Other biological observations: resting egg production in the higher test item concentrations
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.