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Diss Factsheets
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EC number: 202-874-0 | CAS number: 100-64-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 110 µg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 182 µg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 11 µg/L
- Assessment factor:
- 100
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 65.6 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 5.3 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 0.53 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 1 mg/kg soil dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
The calculated PNEC aquatic for cyclohexanone oxime is 110 µg/L based on chronic data for algae and aquatic invertebrates. Fish was consistently less sensitive (one order of magnitude) in acute studies thus that chronic data for algae (most sensitive) and Daphnia are regarded to be sufficient for a safe aquatic hazard assessment. Cyclohexanone oxime was shown to be readily biodegradable fulfilling the 10-day window-requirement. It does not show surface active properties and the octanol-water partition coefficient is very low. Relevant distribution to sludge, sediment or soil therefore is highly unlikely. This is corroborated by the 3-h value from a test on inherent biodegradability (Zahn-Wellens test, RL 2) used as an adsorption control: Adsorption was found to be negligible (2.7%). From this same test a NOEC for microorganisms of sewage treatment plants could be derived, being the basis for PNECSTP derivation (PNECSTP: 65.6 mg/L). This is corroborated by a supporting study on activated sludge respiration inhibition.
Conclusion on classification
1 Classification according to Regulation (EC) 2008/1272 (CLP)
Classification according Regulation (EC) 2008/1272 (CLP) is performed independently for acute and chronic hazards. If data for chronic hazards are incomplete (data not available for all three trophic levels), chronic classification is performed both, based on acute data and based on available chronic data and the more stringent outcome is taken for final chronic classification.
Acute hazard category:
The lowest acute aquatic toxicity of three trophic levels was determined for algae (Desmodesmus subspicatus) with an acute EC50 (72 h, growth rate) of 18.24 mg/L.
Thus, no acute classification results from the available acute aquatic ecotoxicity data.
Chronic hazard category:
Using available acute data, decisive for a possible chronic classification is failure or fulfillment of (1) rapid degradability and / or (2) presence or absence of a bioaccumulation potential.
As substitute for an experimentally determined BCF in fish log KOW is taken as an indicator of bioaccumulation potential. As log KOW of the submission substance is clearly below the cut-off value according to CLP of 4.0, the submission substance is regarded as non-bioaccumulative.
Rapid biodegradability according to CLP is given for substances which were assessed as “readily biodegradable” in screening studies (OECD 301) with a minimum of 60% O2-depletion or CO2 -evolution of theoretical maximum within 28 days and at the same time fulfillment of the 10-day-window. This is met by the submission substance. The submission substance is therefore considered as rapidly biodegradable.
No chronic classification results for the submission substance from the available acute data on ecotoxicity, the degradation and bioaccumulation potentials.
Using available chronic data for algae (most sensitive) and invertebrates, from the algae EC10 (96 h, growth rate) of 1.1 mg/L a chronic classification for rapidly degradable substances results. Thus, the final chronic classification according to regulation (EC) 2008/1272 (CLP) is the following:
Category Chronic 3, H 412: Harmful to aquatic life with long lasting effects, no M-factor
2 Classification according Directive 67/548/EEC (DSD)
The lowest acute aquatic toxicity of three trophic levels was determined for algae (Desmodesmus subspicatus) with an acute EC50 (72 h, growth rate) of 18.24 mg/L. The submission substance is considered as rapidly biodegradable and without potential for bioaccumulation (log Kow < 3.0).
Thus, no classification according to Directive 67/548/EEC (DSD) is resulting.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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