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EC number: 643-078-7 | CAS number: 87855-59-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 29 July - 19 November, 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP Study
Data source
Reference
- Title:
- Unnamed
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- GLP compliance:
- yes
Test material
- Reference substance name:
- N-[ethenyl(N-ethylacetamido)methylsilyl]-N-ethylacetamide
- EC Number:
- 643-078-7
- Cas Number:
- 87855-59-2
- Molecular formula:
- C11 H22 N2 O2 Si Si(CH3)(CH=CH2)[N(CH2CH3)(C(=O)CH3)]2
- IUPAC Name:
- N-[ethenyl(N-ethylacetamido)methylsilyl]-N-ethylacetamide
- Test material form:
- solid: compact
- Details on test material:
- Identification: Methylvinyl bis(n-ethylacetamido)silane (supplied as Dow
Coming® 1-6008)
Lot No.: 091217
CAS No.: 87855-59-2
Expiration Date: 26 December 20 I 0
Source: Korea Biogen Co. Ltd., 690 Sinduk-Ri, Sungnam-Myuan,
Chunan-City, Chungnam, 330-893, Korea
Physical Description: Amber Liquid (Stutls, 20 I 0)
Stability: Stable, refer to MSDS
Purity: 77.9 ± 0.3% area % purity (Stutts, :W I 0)
Solubility: Unknown, and/or may be soluble in other common organic solvents
Storage Conditions: Room Temperature
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 72 h
Results and discussion
Effect concentrations
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: 95% CL
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Based on the results, the 72-hour NOEC for growth rate was determined to be 100 mg/L. The 72-hour EC50 was empirically estimated to be > 100 mg/L.
- Executive summary:
The purpose of this study was to determine the effects of the primary hydrolysis products of
methylvinyl bis(n-ethylacetamido)silane on the growth of the freshwater green alga,
Pseudokirchneriella subcapitata, formerly Selenastrum capricornutum, under static conditions.
Based on preliminary range-finding test results and consultation with the Study Sponsor, the
algae were exposed to methylvinyl bis(n-ethylacetamido )silane at nominal concentrations of 6.3,
13, 25, 50 and 100 mg a.i./L. Due to the rapid hydrolysis of the test substance (information
based on previous work and consultation with the study monitor), no attempt was made to
determine the toxicity of parent substance. The results of this study are based on nominal
concentrations.
Three replicate flasks were established for each treatment level and six for the control. At test
initiation, a 0.458-mL inoculum of Pseudokirchneriella subcapi/ata cells, at a density of
218 x 104 cells/mL, was aseptically introduced into each flask. This inoculum provided the
required cell density ofapproximately 1.0 x 104 cells/mL. The cell density in each test vessel
was monitored at 24, 48 and 72 hours after test initiation. Total yield and average specific
growth rate at 72 hours for each replicate vessel were calculated using the observed cell density
values. Temperature, pH and conductivity were measured during the test and were within
acceptable limits.
Cells exposed to all treatment levels tested were observed to be normal after 72 hours of
exposure. The 72-hour cell density in the control averaged 77.42 x 104 cells/mL. Cell density in
the 6.3,13,25,50 and lOO mg a.i.lL treatment levels averaged 83.25, 72.25, 73.58, 84.75 and
62.75 x:.l04 cells/mL, respectively.
The 0- to 72-hour yield in the control averaged 76.42 x 104 cellslmL. The 0- to 72-houryield in
the 6.3, 13,25, 50 and 100 mg a.i.lL treatment levels averaged 82.25, 71.25, 72.58, 83.75 and
61.75 x lif cellslmL, respectively. No significant reduction in 72-hour yield was detected in any
of the treatment levels tested compared to the control data, using WilIiams' Test. Based on these results, the 72-hour NOEC for yield was determined to be 100 mg a.i./L. The 72 hour EC50 was empirically estimated to be > 100 mg a.i./L.
The to 72 hour growth rate in the control averaged 1.50 days. The 0 to72 -hour growth rate
in the 6.3, 13, 25, 50 and 100 mg a.i./L treatment levels averaged 1.52, 1.48, 1.48, 1.53 and
1.43 days, respectively. No significant reduction in 0- to 72-hour growth rate was detected in
any of the treatment levels tested compared to the control data, using Williams' Test. Based on
these results, the 72-hour NOEC for growth rate was determined to be 100 mg a.UL. The
72-hour EC50 was empirically estimated to be > 100 mg a. i./L.
The following acceptance criteria were required by the protocol: the cell growth in the control
must increase from the initial density (1.0 x 104 cellslmL) by more than 16 times after 72 hours
of growth. During this study, the 72·hour cell density in the control was 77.42 x 104 cellslmL,
which exceeds the above criterion. Additionally, the mean coefficient of variation (CV) for
section-by-section specific growth rates (day 0 to I. I to 2 and 2 to 3) in the control replicates
should not exceed 35%. The CV for the average growth rate of the control for the entire test
period (0 to 72-hour growth rate) should not exceed 7%. For this study, the mean daily CV for
grnwth rates was 23% and the CV for 0 to 72 hours average growth rate was 4.0%, which meet
the above criteria.
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