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EC number: 939-783-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
For the test item Reaction product of adipic acid and sebacic acid and isotridecan-1 -ol is no study available. However, it is likely that the studies conducted on the component diisotridecyl adipate and the read-across substance bis(2 -ethylhexyl) adipate are valid for Reaction product of adipic acid and sebacic acid and isotridecan-1 -ol (please see justification for read-across).
The oral LD50 of the component diisotridecyl adipate was determined to be > 15000 mg/kg bw (limit test) (Moreno/Mobil, 1978a). The oral LD 50 of the read-across substance diisotridecyl dodecanedioate in rats was > 2000 mg/kg. There were no significant signs of systemic toxicity (Zeneka, 1995).
The dermal LD50 of the component diisotridecyl adipate was determined to be > 5000 mg/kg bw (Moreno/Mobil, 1978b).
Inhalational toxicity is not expected due to the low vapor pressure of diisotridecyl adipate (data waiving: study technically not feasible/appropriate).
Key value for chemical safety assessment
Additional information
For the test item Reaction product of adipic acid and sebacic acid and isotridecan-1 -ol is no study available. However, it is likely that the studies conducted on the component diisotridecyl adipate and the read-across substances bis(2 -ethylhexyl) adipate and diisotridecyl dodecanedioate are valid for Reaction product of adipic acid and sebacic acid and isotridecan-1 -ol (please see justification for read-across).
Acute oral toxicity
The acute oral toxicity of the component diisotridecyl adipate was determined in a valid acute toxicity study using 5 male and 5 female Wistar rats each receiving 15 g/kg bw of the test material by oral gavage (limit test).
None of the animals died. Clinical signs (diarrhea, lethargy, oily bodies) were observed predominantly during day 0 to 5.
The acute oral LD50 was determined to be > 15000 mg/kg bw in rats (Moreno/Mobil, 1978a).
The read-across substance Bis(2 -ethylhexyl) adipate had a LD50 of 15000 mg/kg in mice (w) and 24600 mg/kg in rats (w). The male animals showed higher LD50 -values: 24600 mg/kg mice (m), 45000 mg/kg rats (m) (NTP, 1982). The oral LD50 of the component diisotridecyl adipate was determined to be > 15000 mg/kg bw (limit test) (Moreno/Mobil, 1978a). The oral LD 50 of the read-across substance diisotridecyl dodecanedioate in rats was > 2000 mg/kg. There were no significant signs of systemic toxicity (Zeneka, 1995).Therefore the oral LD50 -values for the substances are in the same order of magnitude and very high.
Acute dermal toxicity
The acute dermal toxicity of the component diisotridecyl adipate was determined in a valid acute dermal toxicity study using 10 New Zealand White rabbits each receiving a single dose of 5000 mg/kg bw of test substance (limit test). The exposure time was 24 hours followed by an observation period of 14 days. Before application of test substance, the clipped skin of half of the test animals was abraded. At the end of the exposure period, the skin was cleansed.
No mortality was observed during the test. Two animals showed signs of emaciation. Other clinical observations were diarrhea (4 animals), and in single animals lethargy and bloated abdomen. Body weight development was below normal.
The acute dermal LD50 was determined to be > 5000 mg/kg bw in rats (Moreno/Mobil 1978b).
For the read-across substance Bis(2 -ethylhexyladipate) the LD50 in rabbits was 15100 mg/kg (Smyth et al., 1951, cited in BUA, 1997.) . Thus both substances show a very low hazard for acute toxicity.
Acute Inhalation toxicity
The vapor pressure of the component diisotridecyl adipate is estimated to be 6.64E-07. Thus atmosphere concentrations which can be reached are too low to exert toxic effects. Nelson et. al. (1990) have investigated series of alcohols showing that alcohols with a chain length from C5 on upward do not cause toxic effects due to low atmosphere concentrations achievable (.Journal of the American College of Toxicology 1990 (9): 93-97; Toxicol and Industrial Health 1990 (6): 373-387) (data waiving: study technically not feasible).
BUA, 1997, Di-(2 -ethylhexyl)adipate, BUA-Bericht 196, S. Hirzel Wissenschaftliche Verlagsgesellschaft
ZENECA Central Toxicology Laboratory, 1995, Acute oral toxicity to the rat, CTL Report No.: CTL/L/6460
Justification for classification or non-classification
Acute oral toxicity
The acute LD50 in rats was > 15,000 mg/kg bw. This exceeds by far the cut-off value for classification according to EU regulations (Directive 67/548/EEC and Regulation (EC) No 1272/2008.
Acute dermal toxicity
The dermal LD50 in rats was > 5000 mg/kg bw. This exceeds clearly the cut-off value for classification according to EU regulations (Directive 67/548/EEC and Regulation (EC) No 1272/2008.
Overall, the acute oral and dermal toxicity of Reaction product of adipic acid and sebacic acid and isotridecan-1 -ol is low and does not require classification.
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