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EC number: 613-147-6 | CAS number: 63141-09-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 27 Jul - 19 Okt 2001
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Remarks:
- Nevertheless, the experimental study was conducted according to EEC Method (92/69/EEC C.7) and is GLP compliant. Results of the preliminary test showed that the test substance is hydrolytically stable as less than 10% were degraded within 5 days at pH 4, 7 and 9. Therefore, the results are considered reliable.
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Version / remarks:
- 92/69
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Buffers:
- At pH value = 9 and 50 °C:
buffer: borax / hydrochloric acid,
Riedel de Haen Art. No. 33548, ready to use solution
At pH value = 7 and 50 °C:
buffer: potassium dihydrogen phosphate / Di-sodium hydrogen phosphate,
Riedel de Haen Art. No. 33546, ready to use solution
At pH value = 4 and 50 °C:
buffer: citric acid / potassium hydroxide / sodium chloride,
Riedel de Haen Art. No. 33543, ready to use solution - Preliminary study:
- At pH value = 9 and 50 °C:
Within five days the degradation was less than 10 %.
At pH value = 7 and 50 °C:
Within five days the degradation was less than 10 %.
At pH value = 4 and 50 °C:
Within five days the degradation was less than 10 %. - Transformation products:
- no
- % Recovery:
- > 90
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 5 d
- Remarks on result:
- hydrolytically stable based on preliminary test
- % Recovery:
- > 90
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 5 d
- Remarks on result:
- hydrolytically stable based on preliminary test
- % Recovery:
- > 90
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 5 d
- Remarks on result:
- hydrolytically stable based on preliminary test
- Remarks on result:
- hydrolytically stable based on preliminary test
- Validity criteria fulfilled:
- no
- Remarks:
- See "Any other information on results incl. tables"
- Conclusions:
- Within five days the degradation was less than 10 % at pH = 4, 7, 9 at 50 °C.
- Executive summary:
The experimental protocol is comparable to preliminary test of the EU method C.7 (Degradation: Hydrolysis as a function of pH). Aliquots of the dilutions were taken and tempered at 50°C for 5 days. The solutions were analysed by HPLC. The experiments using buffers at pH 4, pH 7 and pH 9 showed that the test substance is not degradable in contact with water. Within five days the degradation was less than 10 %.
Reference
Target condition according to guideline: | Actual condition according to the study: | Validity criteria met: |
The analytical method must be sufficiently precise and sensitive to detect a reduction of 10 % of the initial concentration. | Analysis via HPLC is sensitive enough to detect a reduction of 10% of the initial concentration. | Yes |
Test 1: A sufficient number of samples (not less than four) should be chosen to cover the range 20 to 70 % of hydrolysis to test for pseudo-first order behaviour at the specified pH values. | Within five days the degradation was less than 10 %. If the preliminary test indicates that less than 10 % has been hydrolyzed after five days at each of the three pH values (4, 7 and 9), no further testing is necessary. | Yes |
For each test: the temperature, pH value, buffer composition and a table of all concentration-time data points shall be stated. | The temperature, pH value, buffer composition and a table of all concentration-time data points are not stated. Nevertheless, the study is GLP compliant including a QA statement. Results of the preliminary test showed that the test substance is hydrolytically stable as less than 10% were degraded within 5 days at pH 4, 7 and 9. Therefore, the results are considered reliable. | No |
Description of key information
The experimental protocol is comparable to preliminary test of the EU method C.7 (Degradation: Hydrolysis as a function of pH). Aliquots of the dilutions were taken and tempered at 50°C for 5 days. The solutions were analysed by HPLC. The experiments using buffers at pH 4, pH 7 and pH 9 showed that the test substance is not degradable in contact with water. Within five days the degradation was less than 10 %.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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