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EC number: 201-178-4 | CAS number: 79-11-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 29 Aug - 2 Sep 2005
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP - Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Circular on Test Methods of New Chemical Substances (Japan), fish acute toxicity test
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Chloroacetic acid
- EC Number:
- 201-178-4
- EC Name:
- Chloroacetic acid
- Cas Number:
- 79-11-8
- Molecular formula:
- C2H3ClO2
- IUPAC Name:
- chloroacetic acid
- Test material form:
- solid: crystalline
- Details on test material:
- - Name of test material (as cited in study report): Chloroacetic acid
- Physical state: non colored crystalline
- Analytical purity: 100%
_ Vapour pressure: 1 hPa at 20°C
-Water solubility: 45% at 20 °C
- Lot/batch No.: 610C2140
- Stability under test conditions: stable, verified by IR.
- Storage condition of test material: in the cool and dark
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 0, 20, 30, 45, 67, and 100 mg/L, dilution factor: 1.5
- Sampling method: test water was sampled at the study initiation, 24 hours before water change, 48 hours after water change and 72 hours before water exchange.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: The stock solution was prepared by dissolving 500 mg test substance in dilution water. The nominal concentration of the stock solution was 100 mg/l. Following this, appropriate volumes of the stirring stock solution were added respectively into the test vessels containing 5 Liter test dilution water to obtain the desired test concentrations, no vehicle was applied.
Test organisms
- Test organisms (species):
- Oryzias latipes
- Details on test organisms:
- TEST ORGANISM
- Common name: Medaka (Japanes rice fish)
- Strain: Oryzias latipes
- Source: Amishima Fishing, Yokohama, Japan
- Age at study initiation (mean and range, SD): ca 6 months.
- Length at study initiation (length definition, mean, range and SD): 2.33 cm (2.12 - 2.52 cm), n=10
- Weight at study initiation (mean and range, SD): 0.068 g (0.054 - 0.079 g), n=10
- Feeding during test: no food
ACCLIMATION
- Acclimation period: 7 days
- Type and amount of food: Tetramine, 2% of body weight
- Health during acclimation (any mortality observed): Mortality of 7 days before exposure was <5%.
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- 55 mg/L (as CaCO3)
- Test temperature:
- 23.7 - 24.0 °C, measured every 24 hours at the change of test solutions
- pH:
- 3.2 - 7.5, measured every 24 hours at the change of test solutions
- Dissolved oxygen:
- 6.4 - 8.3 mg/L, measured every 24 hours at the change of test solutions
- Nominal and measured concentrations:
- Nominal concentration: 0, 20, 30, 45, 67, 100 mg/L
Measured concentration (TWA): 0, 19.2, 29.8, 43.5, 65.1, 99.1 mg/L
Recovery of test substance is > 80% - Details on test conditions:
- TEST SYSTEM
- Test vessel: glass vessel
- Type (delete if not applicable): close, covered with teflon film
- Material, size, headspace, fill volume: Glass, 5.0 L
- Renewal rate of test solution (frequency/flow rate): every 24 hours
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: tap water in Yokohama-city was treated with active charcoal to remove residual chlorine and aerated.
- Alkalinity: 44 mg/L
- Ca/mg ratio: 14/4.2
- Culture medium different from test medium: same medium
- Intervals of water quality measurement: every 6 months
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 hours in light/8 hours in dark
- Light intensity: < 1000 lux
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
LC50, highest concentration in 0% mortality, lowest concentration in 100% mortality
TEST CONCENTRATIONS
- Range finding study: performed
- Test concentrations: 10, 30, 100 mg/L
- Results used to determine the conditions for the definitive study: In 10 mg/L, 0% mortality after 96 hours and no toxicological effect was observed. In 30 mg/L, mortality after 96 hours was 0% but toxicological effect was observed. In 100 mg/L, mortality after 96 hours was 100%. - Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 71.7 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- test mat.
- Remarks:
- without pH adjustment
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 43.5 - 99.1 mg/L
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- 43.5 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- test mat.
- Remarks:
- without pH adjustment
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- 99.1 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- test mat.
- Remarks:
- without pH adjustment
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 72.5 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- test mat.
- Remarks:
- with pH adjustment
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 44.1 - 98.9 mg/L
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- 44.1 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- test mat.
- Remarks:
- with pH adjustment
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- 98.9 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- test mat.
- Remarks:
- with pH adjustment
- Basis for effect:
- mortality (fish)
- Details on results:
- - Behavioural abnormalities: No abnormalities were observed in 0, 20, 30 and 45 mg/L. In 67 mg/L, one animal showed paralyzation and dead, thereafter. In 100 mg/L, all animals were dead after 24 hours.
- Mortality of control: 0%
- Other adverse effects control: No adverse effects
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values: Test water was always colorless during test in all concentrations. - Reported statistics and error estimates:
- Either Probit test, moving average test or binomial test was applied for LC 50.
Any other information on results incl. tables
- Sublethal observations / clinical signs:
There was no significant effect of pH change on the toxiicty to fish observed.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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