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Diss Factsheets
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EC number: 236-691-2 | CAS number: 13465-08-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
No studies were located concerning the potential skin irritation or corrosion of hydroxylammonium nitrate. Hydroxylammonium sulphate, an analogue of the test chemical, was considered to be moderately irritating to the eyes of a rabbit.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no study available
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- 1989
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Insufficient details about the study design and results reported. Only one animal was used for testing purposes.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- No data.
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- 0.1ml of hydroxylammonium sulphate.
- Duration of treatment / exposure:
- No data.
- Observation period (in vivo):
- 8 days
- Number of animals or in vitro replicates:
- 1
- Details on study design:
- No data.
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hours
- Score:
- 1.3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 8 days
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 24 hours
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: No effect
- Irritant / corrosive response data:
- Conjunctival redness of 3, conjunctival edema mean score of 1.3. Mean scores was determined from appearance at 24, 48 and 72 hours). Iritis (grade 1) was detected on day 1 only, no corneal response was observed. No conjunctival irritation was observed after 8 days.
- Interpretation of results:
- moderately irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
- Conclusions:
- Hydroxylammonium sulphate (0.1ml) is considered to be cause moderate eye irritation in rabbits resulting in conjunctival redness, conjunctival edema and iritis. Effects were resolved after 8 days.
- Executive summary:
In a Draize eye irritation study, hydroxlammonium sulphate caused moderate eye irritation in rabbits after a single dose of 0.1 ml. Conjunctival redness, conjunctival edema and iritis were observed but had completly resolved after 8 days.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
No specific studies were located regarding the potential for hydroxylammonium nitrate to cause irritation or corrosion. However studies located for the sensitization and repeated dose (dermal) toxicity indicate that the chemical may cause dermatitis. Hydroxylammonium sulphate, an analogue of hydroxylammonium nitrate, was found to cause moderate irritation to the eyes of a rabbit in a Draize test. However, although the study was conducted to a recognised protocol, only one rabbit was used in the study.
Justification for selection of eye irritation endpoint:
Only one study was located concerning the potential eye irritation of hydroxylammonium sulphate, an analogue of hydroxylammonium nitrate.
Effects on eye irritation: moderately irritating
Justification for classification or non-classification
No studies were located to confirm the potential irritancy of the substance to skin, although studies located for the sensitisation study and repeated dose toxicity (dermal application) indicate that it can cause chronic and ulcerative dermatitis. Hydroxylammonium nitrate is classified as Skin Irrit 2 and Eye Irrit 2.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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