N,N',N'',N'''-tetrakis(4,6-bis(butyl-(N-methyl-2,2,6,6-tetramethylpiperidin-4-yl)amino)triazin-2-yl)-4,7-diazadecane-1,10-diamine

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: information from migrated NONS file as per inquiry # [06-0000014790-71-0000], permission to refer granted by ECHA

Data source

Reference

Reference Type:

other: body responsible for the test

Title:

Unnamed

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: OECD guidelines for testing of Chenicals, Guideline No.417; "Toxicokinetics" adopted April 4, 1984

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

N,N',N'',N'''-tetrakis(4,6-bis(butyl-(N-methyl-2,2,6,6-tetramethylpiperidin-4-yl)amino)triazin-2-yl)-4,7-diazadecane-1,10-diamine

EC Number:

401-990-0

EC Name:

N,N',N'',N'''-tetrakis(4,6-bis(butyl-(N-methyl-2,2,6,6-tetramethylpiperidin-4-yl)amino)triazin-2-yl)-4,7-diazadecane-1,10-diamine

Cas Number:

106990-43-6

Molecular formula:

C132H250N32

IUPAC Name:

N,N',N'',N'''-tetrakis(4,6-bis(butyl-(N-methyl-2,2,6,6-tetramethylpiperidin-4-yl)amino)triazin-2-yl)-4,7-diazadecane-1,10-diamine

Radiolabelling:

yes

Test animals

Species:

other:

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

other: com oil

Details on exposure:

a single dose via oral gavage

No. of animals per sex per dose / concentration:

Male: 4 animals at CA 50mg/kg
Male: 4 animals at CA 1000mg/kg

Details on dosing and sampling:

The purpos of this study is to obtain information on the absorption, distribution and excretion (ADE) of 14C-chimassorb 119 as a function of oral dosage level. This information may be used as an aid in the evaluation and interpretation of other toxicology studies and the study results amy contribute to provide a rational basis of toxicological ris assessment in man.

Results and discussion

Any other information on results incl. tables

After oral dose of 50 and 1000mg of 14C-chimassorb 119 per kg body weight, the excretion of total radioactivity in virtually complete within 96 hours after administration. Radioactivity is excreted nearly entirely via faeces (96 -99% of recovered radio label). Renal excretion is very low (0.28 -0.60% of the dose), and excretion of radio activity via expired arie negligible (<=0.01% of the dose). There is hardly any retention of radio activity in tissues. There was no significant bioconcentration or accumulation in any of the organs in vestigated.