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EC number: 231-104-6 | CAS number: 7439-95-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Materials and methods well described; results presented properly in the text and tables.
Data source
Reference
- Reference Type:
- publication
- Title:
- Effects of long-term dietary intake of magnesium on rat liver transcriptome.
- Author:
- Martin H, Staedtler F, Lamboley C, Adrian M, Schumacher MM, Chibout SD, Laurant P, Richert L, Berthelot A.
- Year:
- 2 007
- Bibliographic source:
- Magnes Res. 2007 Dec;20(4):259-65.
Materials and methods
- Type of study / information:
- InvestigatIon the effect of a two-year treatment period with a diet containing 3.2g, 0.8 g and 0.15 g Mg/kg, on the rat liver transcriptome.
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- mRNA expression in rat liver
- GLP compliance:
- no
Test material
- Reference substance name:
- Magnesium oxide
- EC Number:
- 215-171-9
- EC Name:
- Magnesium oxide
- Cas Number:
- 1309-48-4
- IUPAC Name:
- magnesium oxide
- Test material form:
- solid: compact
- Details on test material:
- - Name of test material (as cited in study report): magnesium oxide
Constituent 1
Results and discussion
Any other information on results incl. tables
The present work gives further evidence that the Mg content in the diet has pleiotropic effects on liver and impacts different pathways including metabolism, cytoarchitecture (connective tissue/cell adhesion/cytoskeleton), channels/transporters, turn-over (nucleic acid and protein), and homeostasis (stress/DNA damage/apoptosis/ageing). Taken together, these results suggest that a chronic low Mg dietary intake participates in an acceleration of ageing and liver dysfunction, thus having a strong impact on human health recommendations.
A treatment dependent decrease in plasmatic magnesium concentration was found. 0.86 +/- 0.02 mmol/L, 0.70 +/- 0.02 mmol/L and 05.2 +/- 0.03 mmol/L for groups receiving 3.2 g, 0.8 g and 0.15 g Mg/kg diet, respectively. No significant treatment-related effect on body and liver weights were observed. Magnesium dose-dependently increased the mortality rate. Magnesium content in diet affected gene expression in rat livers, as assessed by rat specific DNA microassays.
Applicant's summary and conclusion
- Conclusions:
- The present work gives further evidence that the Mg content in the diet has pleiotropic effects on liver and impacts different pathways including metabolism, cytoarchitecture (connective tissue/cell adhesion/cytoskeleton), channels/transporters, turn-over (nucleic acid and protein), and homeostasis (stress/DNA damage/apoptosis/ageing). Taken together, these results suggest that a chronic low Mg dietary intake participates in an acceleration of ageing and liver dysfunction, thus having a strong impact on human health recommendations.
A treatment dependent decrease in plasmatic magnesium concentration was found. 0.86 +/- 0.02 mmol/L, 0.70 +/- 0.02 mmol/L and 05.2 +/- 0.03 mmol/L for groups receiving 3.2 g, 0.8 g and 0.15 g Mg/kg diet, respectively.
No significant treatment-related effect on body and liver weights were observed.
Magnesium dose-dependently increased the mortality rate.
Magnesium content in diet affected gene expression in rat livers, as assessed by rat specific DNA microassays. - Executive summary:
In the present study the autors investigated the effect of a two-year treatment period with a diet containing 3.2g, 0.8 g and 0.15 g Mg/kg, on the rat liver transcriptome. At the end of the study, a treatment-dependent decrease in plasmatic Mg concentration was found (0.86 +/- 0.02 mmol/L, 0.70 +/- 0.02 mmol/L and 0.52 +/- 0.03 mmol/L for groups receiving 3.2g, 0.8 g and 0.15 g Mg/kg diet, respectively). No significant treatment-related effect on body and liver weights was observed, however a dietary Mg intake-dependent increase in mortality rate occurred in animals (11%, 25% and 38% death of animals). Mg content in the diet affected gene expression in rat livers, as assessed by rat specific DNA microarrays. We identified 11 genes up-regulated and 39 genes down-regulated by at least two-fold by a decrease in Mg content and grouped them within five functional pathways: metabolism 20%, cytoarchitecture (connective tissue/cell adhesion/cytoskeleton) 12%, channels/ transporters 20%, turn-over (nucleic acid and protein) 16%, and homeostasis (stress/DNA damage/apoptosis/ageing) 32%. The results of the present study confirm the pleiotropic effects of Mg and provide further evidence that a Mg decrease in the diet may be considered as a promoting factor for pathologies, especially in the liver, during ageing.
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