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EC number: 603-837-5 | CAS number: 134605-64-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to terrestrial arthropods
Administrative data
Link to relevant study record(s)
Description of key information
Contact: LD50 >100 µg a.i./bee, NOEC 100 µg a.i./bee, 48 hours, EPA OPP 141-1, EPPO 170, Palmers & Beavers 1996b
Oral: LD50 >20 µg a.i./bee, NOEC 20 µg a.i./bee, 48 hours, EPPO 170, Palmers & Beavers 1996c
Key value for chemical safety assessment
Additional information
Two key studies have been provided to address the toxicity to terrestrial arthropods, an acute oral and an acute contact study in the honeybee.
Palmer & Beavers (1996b) addressed contact toxicity with Apis mellifera exposed to the test material at 6.25, 12.5, 25, 50 and 100 µg a.i./bee by topical application to the abdomen and/or the thorax. Under the conditions of the test, no treatment related mortalities or signs of toxicity were observed in any of the test groups. One incidental mortality was observed in the 6.25 µg a.i./bee treatment group but this is not considered to relate to treatment with the test material. The LD50 was determined to be >100 µg a.i./bee and the NOEC to be 100 µg a.i./bee.
Palmer & Beavers (1996c) addressed acute oral toxicity with Apis mellifera exposed to the test material at 1.25, 2.5, 5.0, 10 and 20 µg a.i./bee administered in a 50% sucrose solution. Under the conditions of the test percentage mortality at test termination in the 1.25, 2.5, 5.0, 10 and 20 µg a.i./bee treatment groups was 3%, 0%, 3%, 0% and 3%, respectively. The number of mortalities observed was comparable to those of the negative and solvent controls; the observed deaths did not occur in a dose-responsive pattern and are therefore considered to be incidental. One bee in the 1.25 µg a.i./bee dose group and one in the 20 µg a.i./bee dose group was immobile, at approximately 45 minutes after test initiation. All other surviving bees were normal in both appearance and behaviour throughout the test period. The observed clinical signs showed no dose response pattern, thus the observed immobile bees are not considered to be caused by exposure to the test material. Under the conditions of the test, the LD50 was determined to be >20 µg a.i./bee and the NOEC to be 20 µg a.i./bee.
Both studies were performed to a high standard, in line with GLP and in accordance with standardised guidelines. They have thus been assigned a reliability score of 1 in line with the principles for assessing data quality as set out in Klimisch (1997). The available data are deemed to be relevant, reliable and adequate for the purposes of risk assessment.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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