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Diss Factsheets
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EC number: 700-823-1 | CAS number: 55514-22-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
The only aquatic toxicity test performed was toxicity to microorganisms, as no water conscentration control is required. This test lead to the conclusion that no toxicity was observed in a limit test at 100 mg/L nominal concentration of WP30.
Other tests were waived because scientifically injustified, for the following reasons:
1. WP30 solubility limit was measured to be < 0.020 µg/L (limit of detection). Therefore no valid test could be conducted with a water solubility limit that cannot be measured.
2. A weight of evidence approach allows concluding that WP30 is not absorbed in living cells, relying on following observations
a. Chronic toxicity studies with mammals
a.1.Combined repeated dose and reproduction / developmental screening (oral: gavage) on WP30
This validity 1 study concluded to aNOEL: > 1000 mg/kg bw/day (actual dose received) (male/female) based on test material (No effect observed) after ca. 50 days.
b. Toxicokinetic studies with mammals
b.1.Combined repeated dose and reproduction / developmental screening (oral: gavage) on WP30 : ADME results
WP30 absorption was checked. No significant systemic exposure to the test item was measured throughout 5 weeks, up to 1000 mg/kg/d.
Therefore no bioaccumulation potential was observed based on these study results.
b.2. In vitro skin penetration of WP30 (Human skin)
The mean absorption of applied WP30 on Human skin samples was 0.17 +/- 0.32 % (2 SD) according to SCCS/1358/10 guidance. This means that there is no WP30 absorption through Human skin.
b.3.In vitro skin penetration of WP30 (altered Human skin) (OECD 428)
In vitro absorption through Human skin has been determined according to OECD guidelie 428, on untreated skin, irradiated (UVA and UVB) skin, and tape-stripped and irradiated skin. Absorption was found to be negligible in all conditions.
b.4 Summary
Evidence of lack of absorption of WP30 has been shown in several excised skin permeation models, and mammalian toxicity studies performed, up to 5 weeks daily repeated ingestion.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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