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EC number: 611-084-9 | CAS number: 54041-17-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March - April 1992
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- 1987
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- N-(4-fluorophenyl)-2-hydroxy-N-(propan-2-yl)acetamide
- EC Number:
- 611-084-9
- Cas Number:
- 54041-17-7
- Molecular formula:
- C11H14FN
- IUPAC Name:
- N-(4-fluorophenyl)-2-hydroxy-N-(propan-2-yl)acetamide
Constituent 1
- Specific details on test material used for the study:
- Purity: 99.2 %
Stability in formulation not tested
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Remarks:
- with 2% Cremophor EL (v/v)
- Doses:
- male: 1000, 800 and 500 mg/kg bw
female: 500, 400 and 200 mg/kg bw - No. of animals per sex per dose:
- 5 anmials per sex and dose
- Control animals:
- no
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 726 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 474 mg/kg bw
- Based on:
- test mat.
- Mortality:
- male: 1000 mg/kg group: 4 animals died, 800 mg/kg group: 3 animals died, 500 mg/kg group: no animal died
female: 500 mg/kg group: 3 animals died, 400 mg/kg group: 1 animal died, 200 mg/kg group: no animal died - Clinical signs:
- other: The following signs were observed in males at 500 mg/kg body weight and in females at 200 mg/kg body weight: piloerection, reduced or increased activity, dyspnea, spasmodic state, lateral recumbency, and spastic or staggering gait. In the males, letharg
- Gross pathology:
- Animals that died during the recovery period:
In a few cases, lungs pale, distended; in a few cases, liver dark, pale, mottled, lobular pattern; kidneys pale and mottled; spleen somewhat pale; in one animal, ulcer-like foci in the glandular stomach; in one animal, stomach with clear fluid or yellowish fluid content; in one animal, small intestine slightly reddened, empty; in a few cases, intestinal tract empty, reddened; mesenteric vessels severely injected; in a few cases, abdominal organs not assessable.
Animals sacrificed while moribund:
One animal: liver pale, mottled, lobular pattern; stomach with brown fluid content; glandular stomach reddened; intestinal tract reddened, partially empty.
Animals sacrificed at the end of the recovery period:
For males, no evidence of test substance-related, gross organ damage.
For females, at 500 mg/kg body weight: in a few cases, lungs slightly distended; liver with slight lobular pattern (one animal).
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The substance is harmful if swallowed.
- Executive summary:
Tests were performed to determine the acute oral toxicity to male and female rats. The study was performed in accordance with the OECD Guideline for Testing of Chemicals; Section 4: Health Effects, No. 401 - "Acute Oral Toxicity," adopted February 24, 1987 (1) and in accordance with the Pesticide Assessment Guidelines, Subdivision F, Hazard Evaluation: Human and Domestic Animals, Series 81-1 Acute Oral Toxicity Study (Revised Edition, November 1984) (2).
LD50: Rat male: 726 mg/kg body weight (approximate)
LD50: Rat female: 474 mg/kg body weight (approximate).
Some of the signs that were observed occurred immediately after administration and continued until day 5 maximum. Essentially, the following signs were observed: impaired activity and dyspnea, lethargy, piloerection, spastic or staggering gait, lateral recumbency, increased salivation, atony, convulsions, spasmodic state, no reflexes. Mortalities occurred starting at a dose of 400 mg/kg body weight. The test substance is moderately toxic to rats following acute oral administration.
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