Registration Dossier
Registration Dossier
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EC number: 205-498-5 | CAS number: 141-75-3
Endpoint summary
Administrative data
Description of key information
Butyryl chloride was found to be corrosive to the rabbit skin and to the eyes of rabbits.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Additional information
Skin irritation
In a skin irritation test comparable to OECD guideline 404, butyryl chloride was applied undiluted to the skin of Vienna White rabbits for 3 minutes or 4 hours (two animals per exposure duration) under occlusive conditions (BASF AG, 1979). Observations took place 4 hours, 1, 2 and 8 days post-treatment. Application for both 3 minutes and 4 hours caused necrosis and erythema (mean scores (24 and 48 hours) of 4 (application for 3 minutes) and 4 (application for 4 hours)) and edema (mean scores (24 and 48 hours) of 3 (application for 3 minutes) and 2 (application for 4 hours)) of the skin that remained visible until the end of the observation period (not reversible). Butyryl chloride was judged corrosive to skin.
Eye irritation
In an eye irritation test comparable to OECD guideline 405, 50 µL of the test substance was applied to the conjunctival sac of the eyes of 2 Vienna White rabbits (BASF AG, 1979). Scoring for cornea, conjunctivae, chemosis and iris were performed at 1 hour and 1, 2 and 8 days after application. No iritis was observed, the mean (24 and 48 hours) cornea score was 3, the mean (24 and 48 hours) conjunctivae score was 2 and the mean (24 and 48 hours) chemosis score was 3.3. The effects remained throughout the 8 days observation period and were not reversible. Scar formation was observed at all observation time points. The colour of the nictitating membrane and the mucous membrane was grey 1 hour post-treatment and white 24 and 48 hours and 8 days post-treatment. In one animal strong discharge was observed 8 days post-treatment and therefore scoring of the eyes was not possible. Butyryl chloride was judged corrosive to the eyes.
Justification for classification or non-classification
According to the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008, butyryl chloride needs be classified as follows, skin corrosion Cat 1B (H314) and serious eye damage Cat 1 (H318).
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