Registration Dossier
Registration Dossier
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EC number: 204-451-6 | CAS number: 121-17-5
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1999
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 4-chloro-α,α,α-trifluoro-3-nitrotoluene
- EC Number:
- 204-451-6
- EC Name:
- 4-chloro-α,α,α-trifluoro-3-nitrotoluene
- Cas Number:
- 121-17-5
- Molecular formula:
- C7H3ClF3NO2
- IUPAC Name:
- 1-chloro-2-nitro-4-(trifluoromethyl)benzene
- Details on test material:
- Test: 4-chloro-3-nitro benzotrifluoridee
Description: liquid
Expiry date: December 1999
Purity: 99.2%
Density (at 20°C): 1.537 g/mL
Stability of test article: Stable under storage conditions
Storage conditions: at room temperature away from direct sunlight.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 15 days
- Doses:
- 2000 mg/kg body weight
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths
- Clinical signs:
- other: In two males and in all females, slight scaling was observed and persisted in one male and in one female until test day 11.
- Gross pathology:
- No macroscopic findings observed.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 rat is greater than 2000mg/kg body weight
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