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EC number: 941-224-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1957
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study non-GLP with limited data on study design, however the study was conducted to state of the art methods at that time period. The study is therefore considered adequate, reliable and relevant.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 957
- Report date:
- 1957
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- 7 days observation period
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- trisodium 1,4-dioxo-1,4-bis(pentyloxy)butane-2-sulfonate pentane-1-sulfonate pentane-2-sulfonate
- EC Number:
- 941-224-7
- Molecular formula:
- C14H25O7S.Na
- IUPAC Name:
- trisodium 1,4-dioxo-1,4-bis(pentyloxy)butane-2-sulfonate pentane-1-sulfonate pentane-2-sulfonate
- Test material form:
- other: waxy solid
- Details on test material:
- - Name of test material (as cited in study report): Aerosol AY; sodium diamylsulfosuccinate
- Physical state: White, waxy solid
- Analytical purity: >97%
- Impurities (identity and concentrations): See confidential details
- Composition of test material, percentage of components: See confidential details
- Isomers composition: Not provided
- Purity test date: Not provided
- Lot/batch No.: SPS 900A-MH
- Expiration date of the lot/batch: Not provided
- Stability under test conditions: Good stability in aqueous solution
- Storage condition of test material: Not provided
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: albino
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Not provided
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- water
- Remarks:
- 20% aqueous solution
- Doses:
- 10.0 g/kg, 5.0 g/kg, 2.5 g/kg, 1.25 g/kg
- No. of animals per sex per dose:
- 5 males per dose
- Control animals:
- no
- Details on study design:
- The product (Aerosol AY) was administered to groups of young, male albino rats (5 animals per group) as an 20% aqueous solution at dosages ranging from 1.25 g/kg to 10 g/kg.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 4 650 mg/kg bw
- Based on:
- act. ingr.
- 95% CL:
- > 3 000 - < 7 250
- Mortality:
- Death occurred fairly promptly following lethal doses, usually within one-half to one hour.
From the number and distribution of deaths, the LD50 of the product is calculated as 4650 (3000-7250) mg/kg bw. - Clinical signs:
- other: Survivors exhibited varying degrees of depression for periods up to 24 hours following the dose, but thereafter maintained a normal appearance and behavior for remainder of a 7-day observation period.
- Gross pathology:
- They were sacrificed at the end of this time, and gross autopsy disclosed no pathology that could be attributed to the dose.
Any other information on results incl. tables
Table 1: Aerosol AY: Single Dose to Male Albino Rats by Mouth. Product Administered as a Solution in Water, 1 mL= 0.2 g.
Animal Number |
Body weight in Grams |
Weight Change in 7 Days |
Dosage in g/kg |
Dose in Grams |
Dose in mL of Solution |
Days to Death |
R 9956 |
93 |
- |
10.0 |
0.94 |
4.7 |
<1 |
R 9957 |
107 |
- |
10.0 |
1.08 |
5.4 |
<1 |
R 9958 |
111 |
- |
10.0 |
1.12 |
5.6 |
<1 |
R 9959 |
110 |
- |
10.0 |
1.10 |
5.5 |
<1 |
R 9960 |
102 |
- |
10.0 |
1.02 |
5.1 |
<1 |
|
|
|
|
|
|
|
R 9961 |
110 |
- |
5.0 |
0.55 |
2.75 |
<1 |
R 9962 |
106 |
- |
5.0 |
0.53 |
2.65 |
<1 |
R 9965 |
105 |
20 |
5.0 |
0.53 |
2.63 |
S |
R 9966 |
98 |
28 |
5.0 |
0.49 |
2.45 |
S |
R 9967 |
102 |
34 |
5.0 |
0.51 |
2.55 |
S |
|
|
|
|
|
|
|
R 9968 |
103 |
- |
2.5 |
0.26 |
1.29 |
<1 |
R 9969 |
104 |
34 |
2.5 |
0.26 |
1.30 |
S |
R 9970 |
106 |
20 |
2.5 |
0.27 |
1.33 |
S |
R 9971 |
98 |
37 |
2.5 |
0.25 |
1.23 |
S |
R 9972 |
114 |
49 |
2.5 |
0.29 |
1.43 |
S |
|
|
|
|
|
|
|
R 9877 |
90 |
28 |
1.25 |
0.11 |
0.57 |
S |
R 9880 |
92 |
30 |
1.25 |
0.12 |
0.58 |
S |
R 9881 |
93 |
35 |
1.25 |
0.12 |
0.59 |
S |
R 9884 |
90 |
26 |
1.25 |
0.11 |
0.57 |
S |
R 9890 |
94 |
2 |
1.25 |
0.12 |
0.59 |
S |
S= Survived
LD50= 4.65 (3.00-7.25) g/kg
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral LD50 of Aerosol AY dosed as a 20% aqueous solution to male albino rats is 4.65 (3.00-7.25) g/kg .
- Executive summary:
The test item was administered to groups of young, male albino rats (5 animals per group) as an 20% aqueous solution at dosages ranging from 1.25 g/kg to 10 g active ingredient/kg bw. Death occurred fairly promptly following lethal doses, usually within one-half to one hour, and post-mortem examination revealed moderate to severe hemorrhage of the entire gastrointestinal tract. From the number and distribution of deaths, the LD50 of the product is calculated as 4.65 (3.00-7.25) g/kg. Survivors exhibited varying degrees of depression for periods up to 24 hours following the dose, but thereafter maintained a normal appearance and behavior for remainder of a 7-day observation period. They were sacrificed at the end of this time, and gross autopsy disclosed no pathology that could be attributed to the dose.
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