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EC number: 252-328-0 | CAS number: 35037-73-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation/corrosion: New Zealand white rabbit; strong erythema developed
Eye irritation: New Zealand white rabbit; Cornea diffuse opaque
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Principles of method if other than guideline:
- Small cellulose lobes (2.5 x 2.5 cm²) with ca. 500 µl of 4-trifluoromethoxyphenyl isocyanate was applied to the inner surface of one ear per animal; exposure time was 1 or 2 hours. The test-substance was fixed by a plaster. The post exposure observation time was 7 days.
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Type of coverage:
- semiocclusive
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 1 or 2 hours
- Observation period:
- 7 days
- Number of animals:
- 1 animal/exposure time
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.7
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 d
- Remarks on result:
- other: application: 2 hours
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 6, 7 days
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: application: 2 hours
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 48, 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: application: 2 hours
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 6, 7 days
- Score:
- 1.5
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: application: 2 hours
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0.7
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: application: 1 hour
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 6, 7 days
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: application: 1 hour
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: application: 1 hour
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: 6, 7 days
- Score:
- 1.5
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: application: 1 hour
- Interpretation of results:
- Category 1C (corrosive) based on GHS criteria
- Remarks:
- Based on EU GHS criteria
- Conclusions:
- Up to 24 hours the treated skin areas are within the physiological norm. From day 2 of the post-observation period a strong erythema developed. From day 6 a strong erythema and a moderate edema was found. 4-trifluoromethoxyphenyl isocyanate is irritating.
- Executive summary:
Small cellulose lobes (2.5 x 2.5 cm²) with ca. 500 µL of 4-trifluoromethoxyphenyl isocyanate was applied to the inner surface of one ear per animal; exposure time was 1or 2 hours. The test-substance was fixed by a plaster. The post exposure observation time was 7 days.
Up to 24 hours the treated skin areas are within the physiological norm. From day 2 of the post-observation period a strong erythema developed. From day 6 a strong erythema and a moderate edema was found. 4-trifluoromethoxyphenyl isocyanate is irritating.
Reference
Up to 24 hours the treated skin areas are within the physiological norm. From day 2 of the post-observation period a strong erythema developed. From day 6 a strong erythema and a moderate edema was found.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Principles of method if other than guideline:
- 100 µl test substance was applied into the conjuctival sac of 2 rabbits. Eyes were examinated after application of test substance up to 7 days
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 7 days
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 2 animals
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 2.2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 6, 7 days
- Score:
- 2.2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 6, 7 days
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 6, 7 days
- Score:
- 1.9
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.9
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.8
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 6, 7 days
- Score:
- 0.8
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 7 days
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Remarks:
- Based on EU GHS criteria
- Conclusions:
- The conjunctiva was reddened and moderately swollen; the iris was slight to moderately swollen. The cornea was diffuse opaque. 4-trifluoromethoxyphenyl isocyanate is irriating to the eyes.
- Executive summary:
100 µl test substance was applied into the conjuctival sac of 2 rabbits. Eyes were examinated after application of test substance up to 7 days. During the whole post-observation period the following symptoms were observed: The conjunctiva was reddened and moderately swollen; the iris was slight to moderately swollen. The cornea was diffuse opaque. 4-trifluoromethoxyphenyl isocyanate is irriating to the eyes.
Reference
4-trifluoromethoxyphenyl isocyanate is irriating
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
In the skin irritation/corrosion test up to 24 hours the treated skin areas were within the physiological norm. From day 2 of the post-observation period a strong erythema developed. From day 6 a strong erythema and a moderate edema was found. Within the post-observation time the findings were not reversible.
In the eye irritation test, during the whole post-observation period the following symptoms were observed: The conjunctiva were reddened and moderately swollen; the iris was slight to moderately swollen. The cornea was diffuse opaque. Within the post-observation time the findings were not reversible.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: irritating
Effects on respiratory irritation: irritating
Justification for classification or non-classification
Due to the result of the irreversibility of the findings, for skin irritation/corrsion Skin Corr.1C;H314: Causes severe skin burns and eye damage and for eye irritation Eye Dam.1; H318 according to Regulation (EC) No 1272/2008 is justified.
In addition, respiration irritational effects were reported in the acute inhalation toxicity study (7.2.2). Therefore H335 is applicable.
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