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Diss Factsheets
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EC number: 203-797-5 | CAS number: 110-73-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline comparable, non-GLP proprietray study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- Principles of method if other than guideline:
- BASF in-house test methods similar to those subsequently outlined in OECD acute testing guidelines. The study design is similar to standard acute dermal method described in TG OECD 402
- GLP compliance:
- no
- Test type:
- other: various acute toxicity investigations presented in a single report
- Limit test:
- no
Test material
- Reference substance name:
- ethylethanolamine
- IUPAC Name:
- ethylethanolamine
- Reference substance name:
- 2-ethylaminoethanol
- EC Number:
- 203-797-5
- EC Name:
- 2-ethylaminoethanol
- Cas Number:
- 110-73-6
- Molecular formula:
- C4H11NO
- IUPAC Name:
- 2-ethylaminoethanol
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report):ethylethanolamine
- Physical state: liquid
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No information
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- No information available
- Duration of exposure:
- No information available
- Doses:
- No information
- No. of animals per sex per dose:
- No information
- Control animals:
- not specified
- Details on study design:
- In-house BASF test design, no additional information available. Methods similar to those subsequently adopted for OECD 402
- Statistics:
- Median lethal dose was calculated by Probit analysis using the method of FInney
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 670 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 3 030 - < 5 180
- Mortality:
- Mortalities occurred but no details are presented in the report
- Clinical signs:
- other: Following application vocalising and a'long-legged' gait were noted. The animals were initially aggressive but subsequently apathetic. Persistent necrosis was apparent from 24 h after dosing The only clinical sign observed was apathy
- Gross pathology:
- - Histopathology (decedent animals): cadaveric
- Histopathology (killed animals): no findings - Other findings:
- No information
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The median lethal dose for rats for dermally administered 2-ethylethanolamine was 3670 mg/kg (confidence limit 3030 to 5180 mg/kg)
- Executive summary:
The median lethal dermal dose of 2 -ethylethanolamine to rats was calculated following exposure to the unchanged test material. The rats were apathetic after dosing but no other signs of reaction to treatment were observed. After dermal treatment with 2 -ethylaminoethanol the rats showed clinical signs including screaming, aggression and long-legged gait. In the observation period apathy was observed. Further, necrosis was noted which lasted throughout the observation period. A dermal LD 50 of 3670 (3030-5180) mg/kg bw was calculated.
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