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EC number: 620-341-4 | CAS number: 61358-25-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 - 30 Jan 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP - Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- THE DEPARTMENT OF HEALTH OF THE GOVERNMENT OF THE UNITED KINGDOM
Test material
- Reference substance name:
- bis(4-tert-butylphenyl)iodanium; hexafluoro-λ⁵-phosphanuide
- EC Number:
- 620-341-4
- Cas Number:
- 61358-25-6
- Molecular formula:
- C20H26F6IP
- IUPAC Name:
- bis(4-tert-butylphenyl)iodanium; hexafluoro-λ⁵-phosphanuide
- Details on test material:
- - Name of test material (as cited in study report): PF-6
- Physical state: white powder
- Analytical purity: 98.5%
- Purity test date: 2010-08-12
- Lot/batch No.: 20101020
- Expiration date of the lot/batch: 2012-04-12
- Storage condition of test material: at room temperature in the dark
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: New Zealand White (Hsdlf:NZW)
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Harlan Laboratories UK Ltd., Leicestershire, UK
- Age at study initiation: 12-20 weeks
- Weight at study initiation: 2.1 kg
- Housing: the animal was housed in a suspended cage.
- Diet: 2930C Teklad Global Rodent diet (Harlan Laboratories UK Ltd., Oxon, UK), ad libitum
- Water: mains drinking water, ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 17-23
- Humidity (%): 30-70
- Air changes (per hr): at least 15
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: the untreated eye served as control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.1 mL (volume measured with a syringe, corresponds to 90 mg) - Duration of treatment / exposure:
- single application without washing
- Observation period (in vivo):
- 7 days
Reading time points: 1, 24, 48 and 72 h and 7 days - Number of animals or in vitro replicates:
- 1
- Details on study design:
- SCORING SYSTEM: Draize scoring system
TOOL USED TO ASSESS SCORE: hand-slit lamp
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other: mean after 24/48/72 h
- Score:
- 1.3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: the animal was killed for humane reasons immediately after the 7-day observation period
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: mean after 24/48/72 h
- Score:
- 1
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: mean after 24/48/72 h
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- other: mean after 24/48/72 h
- Score:
- 2.3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Irritant / corrosive response data:
- Single application of the test substance to the eye of one rabbit induced scattered or diffuse corneal opacity at the 24 and 48 h readings. Translucent corneal opacity was observed 72 h and 7 days post-application. In addition, a small area of opalescent corneal opacity was observed at the 72 h reading and blood stained discharge occurred 7 days post-application. Iridial inflammation was noted in the animals at the 24, 48 and 72 h readings as well as 7 days after test substance application. Moderate to severe conjunctival redness and chemosis were observed in the animal at the 24, 48 and 72 h as well as the 7 day observation time points. All effects on the treated eye were not reversible within the 7-day observation period.
- Other effects:
- Due to worsening reactions and signs of pain and discomfort, the animal was killed for humane reasons immediately after the 7-day observation period.
Any other information on results incl. tables
MEASUREMENT OF pH
The pH of the test substance at 10% (w/v) in aqueous solution was 4.5 (immediately) or 4.1 (after 10 min).
RABBIT ENUCLEATED EYE TEST
In the preliminary Rabbit Enucleated Eye Test (REET), the test substance was not found to cause effects on corneal thickness, corneal opacity, corneal epithelium, and fluorescein uptake in the enucleated eyes of New Zealand white rabbits.Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- CLP: Eye Dam. 1, H318
DSD: Xi, R41 - Executive summary:
The eye irritation potential of PF-6 was investigated according to OECD guideline 405 and in compliance with GLP. The undiluted test material (0.1 mL) was placed into the conjunctival sac of one eye of 1 New Zealand White (Hsdlf:NZW) rabbit. The other eye remained untreated and served as control. The eyes were examined and scored 1, 24, 48 and 72 h as well as 7 days after application. Single application of the test substance to the eye of one rabbit induced scattered or diffuse corneal opacity at the 24 and 48 h readings. Translucent corneal opacity was observed 72 h and 7 days post-application. In addition, a small area of opalescent corneal opacity was observed at the 72 h reading and blood stained discharge occurred 7 days post-application. Iridial inflammation was noted in the animals at all reading time points during the 7-day observation period. Moderate to severe conjunctival redness and chemosis were observed in the animal at the 24, 48 and 72 h as well as the 7 day observation time points. None of the observed effects on the treated eye was reversible within the 7-day observation period. Due to worsening reactions and signs of pain and discomfort, the animal was killed for humane reasons immediately after the 7-day observation period. The mean cornea, iris, conjunctivae and chemosis scores after 24, 48, and 72 h were 1.3, 1, 2 and 2.3 in the animal, respectively.
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