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EC number: 222-376-7 | CAS number: 3452-97-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
- Endpoint:
- biochemical or cellular interactions
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented publication/study report which meets basic scientific principles. However, there is no CAS number given. The exact chemical structure remains therefore unclear and it cannot be excluded that another isomer was used.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 984
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 963
- Report date:
- 1963
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Deviations:
- not applicable
- Principles of method if other than guideline:
- Mechanistic study comparing the effects of phthalate and adipate esters with the corresponding alcohols
- GLP compliance:
- not specified
- Type of method:
- other: in vivo and in vitro
Test material
- Reference substance name:
- 3,5,5-trimethylhexan-1-ol
- EC Number:
- 222-376-7
- EC Name:
- 3,5,5-trimethylhexan-1-ol
- Cas Number:
- 3452-97-9
- Molecular formula:
- C9H20O
- IUPAC Name:
- 3,5,5-trimethylhexan-1-ol
- Details on test material:
- Isononanol was obtained from ICI PLC, Wilton, U.K.
However, there as no CAS number was reported the exact chemical structure remains therefore unclear and it cannot be excluded that another isomer was used, i.e. the test material identity remains unclear.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Alderley Park Wistar-derived
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 14 days
- Frequency of treatment:
- daily
- Post exposure period:
- none
Doses / concentrations
- Remarks:
- Doses / Concentrations:
1 mmol/kg bw/day (= 130 mg/kg bw/day)
Basis:
actual ingested
- No. of animals per sex per dose:
- 5 rats per test group
- Control animals:
- yes, concurrent vehicle
Results and discussion
Any other information on results incl. tables
Result of in-vivo experiments:
Table 1
Controls |
Isononanol |
|
Body weight gain |
118 ± 8 |
111 ± 11 |
Liver: body weight ratio x 100 |
5.21 ± 0.26 |
5.59 ± 0.25 |
Testis: body weight ratio x 100 |
1.00 ± 0.04 |
1.01± 0.07 |
Peroxisomes (No. per 504 µm²) |
6.1 ± 2.6 |
7.7 ± 2.6 |
Catalase (ks/g) |
26.1 ±7.0 |
32.4 ± 2.0 |
Cholesterol (mg/100 ml) |
43 ± 7 |
136 ± 26 |
Triglycerides (mg/100 ml) |
114 ±23 |
137 ± 25 |
Liver histology Incidence of : Slight centrilobular hypertrophy Slight/moderate glycogen vacuolation Slight/moderate centrilobular “fat” vacuolation |
4/10 9/10 6/10 |
1/5 5/5 1/5 |
Table 2
Group |
Concentration (mM) |
Acyl CoA oxidase (nmol NADH/mg/min) |
% Control |
control |
- |
0.71 / 0.844 / 0.774 |
100 |
Isononanol |
0.1 |
1.159 ± 0.194* |
150 |
control |
- |
0.71 / 0.844 / 0.774 |
100 |
Isononanol |
0.1 |
1.159 ± 0.194* |
150 |
Applicant's summary and conclusion
- Conclusions:
- Not asignable: test substance identity unclear. In a 2-week oral study, rats dosed with 1 mmol/kg 3,5,5-trimethylhexanol showed some liver enlargement but no testicular atrophy, hepatic peroxisome induction, or hypolipidemia
- Executive summary:
Isononanol was administered by gavage for 14 days to male rats (Alderly Park Wistar-derived) at a dose equivalent to 1 mmol/kg/day (i.e, 144 mg/kg bw/day). This dose was selected, because administration of 6000 ppm DEHP (approx. 1 mmol/kg/day) produced hepatocellular tumors.
It could be demonstrated, that isononanol did not induce testicular atrophy, hepatomegaly, peroxisome proliferation or hypolipidaemia, while DEHP did produce liver effects.
It was therefore suggested that the alcohol does not produce the effects that were seen with the corresponding phthalate ester (Rhodes et al., 1984).
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