Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Sensitisation data (human)

Currently viewing:

Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Secondary literature

Data source

Reference
Reference Type:
publication
Title:
The results of skin testing with food additives and the effect of an elimination diet in chronic and recurrent uticaria and recurrent angioedema.
Author:
Malanin and Kalimo
Year:
1989
Bibliographic source:
Clin. Exper. Allergy 19: 539-543 [as cited in SIDS Document for SIAM 25-Propionic acid, 01-07-2007

Materials and methods

Type of sensitisation studied:
skin
Study type:
study with volunteers
Principles of method if other than guideline:
Pin prick trials
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Propionic acid
EC Number:
201-176-3
EC Name:
Propionic acid
Cas Number:
79-09-4
Molecular formula:
C3H6O2
IUPAC Name:
propanoic acid
Details on test material:
no data

Method

Type of population:
other: Patients suffering from chronic urticaria
Controls:
non-urticria individual
Route of administration:
dermal

Results and discussion

Results of examinations:
A reproducible positive pin-prick response to a 5% aqueous solution of propionic acid was obtained in 3 of 91 patients suffering from chronic uticaria; patients were presumed to have prior exposure with propionic acid as a food preservative. There was no response observed among 247 normal control (non-uticaria) subjects.

Applicant's summary and conclusion