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Diss Factsheets
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EC number: 203-989-9 | CAS number: 112-60-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not specified but between 9 Dec 1985 and 6 April 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The report does not specify about GLP/Guideline but sufficient data is available for interpretation of results
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3,6,9-trioxaundecane-1,11-diol
- EC Number:
- 203-989-9
- EC Name:
- 3,6,9-trioxaundecane-1,11-diol
- Cas Number:
- 112-60-7
- Molecular formula:
- C8H18O5
- IUPAC Name:
- 2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}ethan-1-ol
- Test material form:
- liquid: viscous
- Details on test material:
- Tetraethylene glycol (Sample No.; 48-349), obtained from UCC plant in Texas City, TX, was used.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- New Zealand White rabbits, weighing between 2.0 and 3.0 kg, were used. The animals are maintained on appropriate commercial diet and municipal water.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Rabbits were subjected to 24 hours of contact with the test material which is retained under impervious sheeting on the clipped, intact skin of the trunk. As necessary for larger doses, gauze is wrapped around the trunk over the sample to prevent leakage. Vetrap® Bandaging Tape is wrapped over the impervious sheeting and the animal is returned to its cage for the contact period.
- Duration of exposure:
- 24 hours
- Doses:
- 16 ml/kg
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- not specified
- Details on study design:
- After the contact period, excess fluid is removed to diminish ingestion. Observations for skin reaction are made at one hour, 7 days and 14 days after the contact period. Five male and 5 females are included on each level used for the LD50 calculation. Animal weights are recorded at 0 days (before dose), 7 days and 14 days (just prior to sacrifice). At death or sacrifice, each animal is subjected to gross pathologic evaluation.
- Statistics:
- LD50's and the estimated LD50 slopes are calculated by the moving average method (Thompson, 1947; Weil, 1983) and are based on a 14-day observation period.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 16 mL/kg bw
- Based on:
- test mat.
- Mortality:
- There was no mortality noted in male or female rabbits exposed dermally to 16 ml/kg tetraethylene glycol for 24 hours.
- Clinical signs:
- other: In male rabbits ,sample residue and edema were observed at day 1. In females rabbits, sample residue, edema and erythema where observed on day 1.
- Gross pathology:
- There were no treatment related gross pathologic observations in male or female rabbits.
- Other findings:
- No additional information available.
Any other information on results incl. tables
Table 1 Male and female rabbit body weights following a 24 hour dermal exposure to tetraethylene glycol.
Day 0 | Day 7 | Day 14 | |
Males | 2679 + 270 | 2743 + 342 | 2846 + 344 |
Females | 2775 + 174 | 2820 + 204 | 3011 + 224 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Tetraethylene Glycol had an extremely low order of toxicity following single dermal application. LD50 was greater than 16ml/kg (>18000mg/kg).
- Executive summary:
The acute dermal toxicity of tetraethylene glycol was examined using New Zealand White rabbits. Tetraethylene Glycol had an extremely low order of toxicity following single dermal application. LD50 was greater than 16ml/kg (>18000mg/kg).
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