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EC number: 219-842-7 | CAS number: 2550-02-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to the justification for grouping of substances provided in IUCLID section 13.
- Reason / purpose for cross-reference:
- read-across source
- Parameter:
- % degradation (DOC removal)
- Value:
- 50
- Sampling time:
- 7 d
- Parameter:
- % degradation (DOC removal)
- Value:
- 55
- Sampling time:
- 14 d
- Parameter:
- % degradation (DOC removal)
- Value:
- 54
- Sampling time:
- 21 d
- Parameter:
- % degradation (DOC removal)
- Value:
- 55
- Sampling time:
- 27 d
- Parameter:
- % degradation (DOC removal)
- Value:
- 54
- Sampling time:
- 28 d
- Interpretation of results:
- other: not readily biodegradable
- Conclusions:
- A biodegradation result of 54% in 28 days was determined in a reliable study conducted according to an appropriate test protocol, and in compliance with GLP.
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1994-08-31 to 1994-11-02
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-A (Determination of the "Ready" Biodegradability - Dissolved Organic Carbon (DOC) Die-Away Test)
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, non-adapted
- Details on inoculum:
- The inoculum employed in the test was activated sludge from the Marl - Ost municipal sewage treatment plant. It was taken off on 1994-09-07 and centrifugated for 15 min at 3000 rpm. The supernatant was rejected and the sludge resuspended with mineral medium (washing). After another centrifugation step 15 min at 3000 rpm, the sludge was resuspended. The content of the dry matter in the inoculum used was 3.45 g/l. The determination of suspended solids was carried out before the inoculum. During this time the sludge had to be aerated by aerating tube. The content of the suspended solids in the test batches was 27.6 mg/l.
- Duration of test (contact time):
- 28 d
- Initial conc.:
- 11.2 mg/L
- Based on:
- DOC
- Parameter followed for biodegradation estimation:
- DOC removal
- Details on study design:
- Vessels: 2000 ml conial flasks with loose aluminium foil closure
Test batches:
2 flasks containing test substance (11.2 mg DOC/l after 3h) and inoculum
2 flasks without test substance, but with inoculum (= blank batch)
2 flasks containing control subsatnce (sodium benzoate: 10.8 mg DOC/l after 3 hours) and inoculum
Method:
Addition of inoculum corresponding to a dry matter content of 27.6 mg/test medium.
Filling up with about 2 l mineral medium.
30 ml/l test substance stock solution (20 ml/l control substance stock solution) were added to the test vessels.
The batches were filled up to 2.5 l with mineral medium.
From this batches two times 1000 ml were put into 2000 ml Erlenmeyer flasks.
The loosely covered flasks were incubated at 21.9 to 22.2 °C in the dark on a mechanical shaker for 28 days. - Reference substance:
- benzoic acid, sodium salt
- Parameter:
- % degradation (DOC removal)
- Value:
- 50
- Sampling time:
- 7 d
- Parameter:
- % degradation (DOC removal)
- Value:
- 55
- Sampling time:
- 14 d
- Parameter:
- % degradation (DOC removal)
- Value:
- 54
- Sampling time:
- 21 d
- Parameter:
- % degradation (DOC removal)
- Value:
- 55
- Sampling time:
- 27 d
- Parameter:
- % degradation (DOC removal)
- Value:
- 54
- Sampling time:
- 28 d
- Details on results:
- Results with reference substance:
98% DOC decrease after 7 days
99% DOC decrease after 14 days
100% DOC decrease after 21 days
99% DOC decrease after 27 days
99% DOC decrease after 28 days - Validity criteria fulfilled:
- yes
- Interpretation of results:
- other: not readily biodegradable
- Conclusions:
- A biodegradation result of 54% in 28 days was determined in a reliable study conducted according to an appropriate test protocol, and in compliance with GLP.
Referenceopen allclose all
DOC measurements of the test item
|
DOC concentration after n days (mg/l) |
||||||||
|
Flask no. |
|
O h (C0) |
3h (C3) |
7 |
14 |
21 |
27 |
28 |
Test batches (Mineral medium + test item + inoculum) |
1 |
a1 |
13.58 |
13.59 |
7.53 |
6.16 |
6.43 |
6.78 |
6.83 |
a2 |
13.32 |
14.13 |
7.41 |
6.31 |
6.43 |
7.02 |
6.74 |
||
Ca (t) = (a1 + a2) /2 |
13.45 |
13.86 |
7.47 |
6.24 |
6.43 |
6.90 |
6.79 |
||
2 |
b1 |
12.25 |
13.78 |
7.04 |
6.74 |
6.62 |
6.28 |
6.61 |
|
b2 |
12.30 |
13.38 |
7.00 |
6.77 |
6.67 |
6.37 |
6.80 |
||
Cb (t) = (b1+ b2) /2 |
12.28 |
13.58 |
7.02 |
6.76 |
6.65 |
6.33 |
6.71 |
||
Blank batches (Mineral medium + inoculum) |
1 |
c1 |
0.52 |
0.36 |
0.61 |
0.50 |
0.43 |
0.60 |
0.62 |
c2 |
0.56 |
0.39 |
0.54 |
0.44 |
0.42 |
0.65 |
0.62 |
||
Cc (t) = (c1 + c2) /2 |
0.54 |
0.38 |
0.58 |
0.47 |
0.43 |
0.63 |
0.62 |
||
2 |
d1 |
0.49 |
0.36 |
0.70 |
0.53 |
0.49 |
0.60 |
0,62 |
|
d2 |
0.44 |
0.41 |
0.68 |
0.49 |
0.49 |
0.61 |
0.59 |
||
Cd (t) 0 (d1 + d2) /2 |
0.47 |
0.39 |
0.69 |
0.51 |
0.49 |
0.61 |
0.61 |
||
|
Cbl(t)=Cc(t)+Cd(t)/2 |
0.51 |
0.39 |
0.64 |
0.49 |
0.46 |
0.62 |
0.62 |
Description of key information
Biodegradation in water, screening tests: A biodegradation rate of 54 % in 28 days
Biodegradation in water, screening tests: Ethanol is readily biodegradable
Key value for chemical safety assessment
Additional information
Note: A biodegradation screening study is currently ongoing for the registered substance (i.e. triethoxy(propyl)silane (CAS 2550-02-9)). This dossier will be updated once the final study report is available.
There are no reliable ready biodegradation data available for triethoxypropylsilane, therefore good quality data for the analogue substance, trimethoxypropylsilane, have been read across. Both substances share the same silanol hydrolysis product, propylsilanetriol; the other hydrolysis products being ethanol and methanol, respectively, which are readily biodegradable.
Both triethoxypropylsilane and trimethoxypropylsilane are within a wider analogue group than the analogue groups discussed in Section 1.4. Substances within this wider analogue group,in general, exhibit no evidence of any significant biodegradation once hydrolysis and subsequent biodegradation of alkoxy/acetoxy groups has been taken into account.
This wider analogue group for the ready biodegradability endpoint consists of a number of sub-classes of substances. However, read-across is carried out between substances within the same sub-class in most cases.
Table 4.1.4 presents ready biodegradation data available for substances within the sub-class (I-2) of alkoxysilanes, silanols, acetoxysilanes and chlorosilanes, etc, where the Si part is of low-biological reactivity, once any hydrolysis is accounted for.
Table 4.1.4 Ready biodegradation data available for substances within the relevant sub-class (I-2) of chemicals
CAS |
Name |
Readily biodegradable? Yes/no |
Result: Biodegradation after 28 day |
Guideline |
Reliability |
Corrected % biodegradation once alkoxy/acetoxy biodegradation is accounted for |
001066-40-6 |
Hydroxytrimethylsilane |
No |
0% |
OECD 310 |
1a |
0 |
018748-98-6 |
Trimethyl(octadecyloxy)silane |
No |
68% |
OECD 301B |
1a |
-18 |
017689-77-9 |
Triacetoxyethylsilane |
Yes |
74% in 21 days |
EC C4-A |
1a |
-1 |
001067-25-0 |
Trimethoxypropylsilane |
No |
54% |
Annex V C4-A |
1a |
4 |
002943-75-1 |
Triethoxyoctylsilane |
No |
31.5% |
OECD 301D |
1a |
-11 |
016415-13-7 |
Triethoxyhexadecylsilane |
No |
43% |
MITI |
1c |
16 |
087135-01-1 |
1,6-Bis(trimethoxysilyl)hexane |
Yes, but not meeting 10-day window |
74% |
OECD 301B |
1a |
24 |
None45 |
Mixture of 1,1- and 1,2-bis(trimethoxysilyl)ethane |
Yes |
93% |
"Biodegradation study of chemical substances by microorganisms and the like " stipulated in "Testing Method for New Chemical Substances etc." ( Kanhogyo No.5, Yakuhatsu 615, 49Kikyoku No.392, July 13, 1974 ) |
1a |
18 |
013154-25-1 |
Chlorotri(3-methyl-propyl)silane |
No |
0% |
OECD 301B |
1a |
0 |
035435-21-3 |
Triethoxy(2,4,4-trimethylpentyl)silane |
No |
13% |
OECD310 |
1a |
-30 |
018395-30-7 |
Trimethoxy(2-methylpropyl)silane |
No |
36 - 47% |
OECD 301B |
1a |
4 |
142877-45-0 |
Silane, trimethoxy(1,1,2-trimethylpropyl)- |
No |
31% |
OECD 301D |
1a |
-2 |
017980-47-1 |
Triethoxyisobutylsilane |
Yes |
75% |
OECD 301D |
1a |
15 |
126990-35-0 |
Dicyclopentyldimethoxysilane |
No |
12% |
OECD 301C |
1 |
-5 |
139147-73-2 |
Silane, dichlorodicyclopentyl- |
No |
0.8% |
OECD 301D |
2b |
1 |
017865-32-6 |
Cyclohexyldimethoxymethylsilane |
No |
15-17% |
OECD 301D |
1a |
-5 |
None46 |
t-butoxycyclopentyldimethoxysilane |
No |
15% |
OECD 301C |
1a |
7 |
000098-12-4 |
Cyclohexyltrichlorosilane |
No |
0% |
OECD 301C |
1a |
0 |
000124-70-9 |
Dichloro(methyl)(vinyl)silane |
No |
-6.78% |
OECD 301A |
1a |
0 |
001067-53-4 |
Tris(2-methoxyethoxy)vinylsilane |
Yes |
89% |
Annex V C4-A |
1a |
7 |
002768-02-7 |
Trimethoxyvinylsilane |
No |
51% |
OECD 301F |
1a |
-9 |
It is therefore considered valid to read-across the results for trimethoxypropylsilane to fill the data gap for the registered substance. Additional information is given in a supporting report (PFA, 2013f) attached in Section 13 of the IUCLID 5 dossier.
A biodegradation rate of 54 % in 28 days was reported for the trimethoxypropylsilane. The results from this study are likely to reflect the biodegradation of methanol, which would biodegrade rapidly (three of the six carbons in trimethoxypropylsilane are converted to methanol in a rapid hydrolysis reaction). Propylsilanetriol is not expected to biodegrade to any significant extent. This is supported by evidence that within a category of small molecule silicon-dominated organosilicon compounds, without reactive functional groups in the side chain, there is no evidence of any significant biodegradation in ready biodegradation tests. The second hydrolysis product ethanol is known to be readily biodegradable.
The study is considered to be reliability 1 (reliable without restrictions); the read across of the result is considered to be reliability 2 (reliable with restrictions).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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