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EC number: 273-734-4 | CAS number: 69012-34-6 By-product from open-hearth steelmaking. Consists of oxides of calcium, iron, silicon and vanadium.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2010-07-01 to 2010-08-04
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study reliable without restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- , adopted 2001-12-17
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- signed 2009-11-12
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Slags, steelmaking, vanadium
- EC Number:
- 273-734-4
- EC Name:
- Slags, steelmaking, vanadium
- Cas Number:
- 69012-34-6
- Molecular formula:
- Substance is a UVCB in mineral form, therefore provision of molecular formula is not technically feasible
- IUPAC Name:
- Slags, steelmaking, vanadium
- Details on test material:
- - Name of test material (as cited in study report): Slags, steelmaking, vanadium (TIAG)
- Trivial name: V slag
- Physical state: Solid, black powder
- Composition of test material, percentage of components: V (13.06%), FeO (28.00%), SiO2 (14.40%), TiO2 (11.40%), Al2O3 (4.90%), CaO (4.70%), MnO (3.80%), MgO (3.40%), P (0.01%), Cr2O3 (5.10%)
- Batch No.: SPH0924
- Expiration date of the batch: December 2015
- Storage condition of test material: Kept dry in tightly sealed containers
- Melting point: > 600°C (EC A.1)
- Water solubility: Approx. 3 mg/L (based on V)
- Description: By-product from open-hearth steel making. Consists of oxides of calcium, iron, silicon and vanadium.
No further information on the test material was stated.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories, Research Models and Services Germany GmbH, Sandhofer Weg 7, 97633 Sulzfeld, Germany
- Age at study initiation: Approx. 7 weeks
- Weight at study initiation: 159 - 177 g
- Fasting period before study: Feeding was discontinued approx. 16 hours before administration.
- Housing: Granulated textured wood (Granulat A2, J. Brandenburg, 49424 Goldenstedt, Germany) was used as bedding material for the cages. During the 14-day observation period the animals were kept in groups of 3 animals in MAKROLON cages (type III plus).
- Diet: Commercial diet, ssniff® R/M-H V1534 (ssniff Spezialdiäten GmbH, 59494 Soest, Germany)
- Water (ad libitum): Drinking water
- Acclimation period: At least 5 adaptation days
ENVIRONMENTAL CONDITIONS
- Temperature: 22°C ± 3°C (maximum range)
- Relative humidity: 55% ± 15% (maximum range)
- Photoperiod (hrs dark / hrs light): 12/12
No further information on the test animals was stated.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: hydroxypropylmethylcellulose
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: The administration volume was 10 mL/kg b.w.
DOSAGE PREPARATION: Slags, steelmaking, vanadium (TIAG) was suspended to the appropriate concentration in 0.8% aqueous hydroxypropylmethylcellulose (Methocel; batch no. 09 D14-N28, Fagron GmbH & Co., 22885 Barsbüttel, Germany).
No further information on the oral exposure was stated. - Doses:
- 2000 mg/kg b.w.
- No. of animals per sex per dose:
- 1 dose level group of 6 female animals
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observations were performed before and immediately, 5, 15, 30 and 60 min, as well as 3, 6 and 24 hours after administration. During the follow-up period of two weeks, changes of skin and fur, eyes and mucous membranes, respiratory and the circulatory, autonomic and central nervous system and somatomotor activity as well as behaviour pattern were observed at least once a day until all symptoms subsided, thereafter each working day. Attention was also paid to possible tremors, convulsions, salivation, diarrhoea, lethargy, sleep and coma.
Observations on mortality were made at least once daily to minimize loss of animals during the study. Individual body weights were recorded before administration of the test item and thereafter in weekly intervals up to the end of the study.
- Necropsy of survivors performed: Yes
All animals were sacrificed, dissected and inspected macroscopically. All gross pathological changes were recorded.
- Examinations performed: Changes in weight were calculated and recorded.
No further information on study design was stated. - Statistics:
- Not applicable
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occurred.
- Clinical signs:
- other: A single oral administration of 2000 mg slags, steelmaking, vanadium (TIAG)/kg b.w. to female rats did not reveal any signs of toxicity. No clinical signs were observed.
- Gross pathology:
- No pathological changes were observed at necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LD50 (rats, females) > 2000 mg/kg b.w. (LD50 cut-off value: 5000 mg/kg b.w.)
According to the EC-Commission Directive 67/548/EEC and its subsequent amendments on the approximation of the laws, regulations and administrative provision relating to the classification, packaging and labelling of dangerous substances and the results obtained under the present test conditions
slags, steelmaking, vanadium is non-toxic if swallowed, hence, no labelling is required.
A
lso, according to the EC Regulation 1272/2008 and subsequent regulations, the test material is not classified for acute oral toxicity.
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