Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 213-510-5 | CAS number: 961-69-3
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
Workers - Hazard for the eyes
Additional information - workers
General Population - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard via oral route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
General principle of read-across is based on: (1) similar physicochemical properties, (2) structural analogy and (3) similar mode of action in the body (toxico-kinetics; biotransformation).
In the case of PG and HPGds, these are all fulfilled:
- Physicochemical parameters were determined;
- Structural similarity is obvious;
- Mode of action/bioavailability/~transformation is the same (action) and not assumed to behave differently.
See the attached documentation for read-across specific motivation for registration of PGds.
Read-across proposed have been checked using the OECD Toolbox v. 1.1.01 and the outcome is the same for both substances.
Dane salts are hydrolysing substances designed to protect a functional group during chemical synthesis, and to easily release the parent molecule. So they can be expected to behave as the parent molecule, as hydrolysis will occur in living organisms or in environment.
Read across from D(-)-p-hydroxyphenylglycine Dane salt (K, methyl, CAS n° 69416-61-1) to D(-)-alpha-phenylglycine Dane salt (K, ethyl, CAS n° 961-69-3) is supported, beyond the structural similarity, by the following mechanistic criteria, similarities, as evaluated by the OECD Toolbox:
- Protein binding: potentially can cause skin sensitization as a result of protein conjugation via Michael-type nucleophilic addition
- No DNA binding potential
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
